Literature DB >> 7236216

The interpretation of entropy/enthalpy compensation phenomena in the deacylation of acyl-alpha-chymotrypsins.

P A Adams.   

Abstract

The thermodynamic-compensation law observed for the deacylation of a series of acyl-alpha-chymotrypsins has been re-examined. From consideration of the effect of small changes in delta delta H+(+)delta T along a homologous series, it is suggested that the high Tc value of 420 K observed for the process has its origin in the solvation of the acyl-group-catalyst transition state.

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Year:  1980        PMID： 7236216      PMCID： PMC1162259          DOI： 10.1042/bj1910653

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  4 in total

1.  Activation parameters of elastase and chymotrypsin catalyzed hydrolysis. Differential role of favorable enthalpy in determining reactivity.

Authors:  T H Marshall; V Chen
Journal:  J Am Chem Soc       Date:  1973-08-08       Impact factor: 15.419

2.  The role of entropy and enthalpy factors in kinetic specificity of -chymotrypsin. Temperature dependence study of acyl- -chymotrypsins deacylation.

Authors:  K Martinek; V N Dorovska; S D Varfolomeyev; I V Berezin
Journal:  Biochim Biophys Acta       Date:  1972-06-22

3.  Studies of the chymotrypsinogen family of proteins. XVI. Enthalpy-entropy compensation phenomenon of -chymotrypsin and the temperature of minimum sensitivity.

Authors:  R Lumry; S Rajender
Journal:  J Phys Chem       Date:  1971-05-13

4.  The effect of temperature on the individual stages of the hydrolysis of non-specific-p-nitrophenol esters by alpha-chymotrypsin.

Authors:  P A Adams; E R Swart
Journal:  Biochem J       Date:  1977-01-01       Impact factor: 3.857
  4 in total
  1 in total

1.  Chymotrypsin compensation plots: a cautionary note.

Authors:  M H Klapper; K C Calvo; C A Wang
Journal:  Biochem J       Date:  1981-08-01       Impact factor: 3.857
  1 in total

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