Literature DB >> 7233243

Exposure of rats to alcohol in utero alters drug sensitivity in adulthood.

E L Abel, R Bush, B A Dintcheff.   

Abstract

Pregnant rats were intubated with alcohol (ethanol, 3 grams per kilogram) twice daily throughout gestation. Control animals received solutions of isocaloric sucrose. At birth, offspring were placed with untreated surrogate dams. Beginning at 6 months of age, the offspring were tested for their thermogenic responsiveness to various drugs and to cold. Prenatal exposure to alcohol resulted in tolerance to alcohol and cross-tolerance to pentobarbital and diazepam but did not affect responsiveness to cold. This pattern of effects suggest that prenatal exposure to alcohol produces specific long-term effects on the neural mechanisms underlying drug tolerance.

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Year:  1981        PMID： 7233243     DOI： 10.1126/science.7233243

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  11 in total

1.  The development of thermoregulation after prenatal exposure to alcohol in rats.

Authors:  B Zimmerberg; G A Ballard; E P Riley
Journal:  Psychopharmacology (Berl)       Date:  1987       Impact factor: 4.530

2.  Effects of prenatal alcohol and cigarette exposure on offspring substance use in multiplex, alcohol-dependent families.

Authors:  Jessica W O'Brien; Shirley Y Hill
Journal:  Alcohol Clin Exp Res       Date:  2014-12       Impact factor: 3.455

Review 3.  Consilient research approaches in studying gene x environment interactions in alcohol research.

Authors:  Kenneth J Sher; Danielle M Dick; John C Crabbe; Kent E Hutchison; Stephanie S O'Malley; Andrew C Heath
Journal:  Addict Biol       Date:  2010-04       Impact factor: 4.280

4.  Prenatal ethanol exposure leads to greater ethanol-induced appetitive reinforcement.

Authors:  Ricardo M Pautassi; Michael E Nizhnikov; Norman E Spear; Juan C Molina
Journal:  Alcohol       Date:  2012-06-12       Impact factor: 2.405

5.  Using drinking in the dark to model prenatal binge-like exposure to ethanol in C57BL/6J mice.

Authors:  Stephen L Boehm; Eileen M Moore; Cherie D Walsh; Carly D Gross; Austin M Cavelli; Eduardo Gigante; David N Linsenbardt
Journal:  Dev Psychobiol       Date:  2008-09       Impact factor: 3.038

6.  Effects on psychological performance of the benzodiazepine, loprazolam, alone and with alcohol.

Authors:  I C McManus; S I Ankier; J Norfolk; M Phillips; R G Priest
Journal:  Br J Clin Pharmacol       Date:  1983-09       Impact factor: 4.335

7.  Thiamine deficiency in utero alters response to ethanol in adulthood.

Authors:  P R Martin; S Levin; G Impeduglia; Y Choe; J Karanian; A B Mukherjee
Journal:  Psychopharmacology (Berl)       Date:  1989       Impact factor: 4.530

8.  Acute sensitivity and acute tolerance to ethanol in preweanling rats with or without prenatal experience with the drug.

Authors:  Carlos Arias; Juan Carlos Molina; Estela C Mlewski; Ricardo Marcos Pautassi; Norman Spear
Journal:  Pharmacol Biochem Behav       Date:  2008-02-23       Impact factor: 3.533

9.  Prenatal ethanol exposure increases ethanol intake and reduces c-Fos expression in infralimbic cortex of adolescent rats.

Authors:  Maria Carolina Fabio; Samanta M March; Juan Carlos Molina; Michael E Nizhnikov; Norman E Spear; Ricardo Marcos Pautassi
Journal:  Pharmacol Biochem Behav       Date:  2012-12-22       Impact factor: 3.533

10.  Maternal alcohol consumption increases sphingosine levels in the brains of progeny mice.

Authors:  S Dasgupta; J A Adams; E L Hogan
Journal:  Neurochem Res       Date:  2007-08-15       Impact factor: 4.414
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