Literature DB >> 7233211

Genetically determined deficiency of the third component of complement in the dog.

J A Winkelstein, L C Cork, D E Griffin, J W Griffin, R J Adams, D L Price.   

Abstract

A genetically determined deficiency of the third component of complement (C3) has been identified in a colony of Brittany spaniels. Immunochemical methods show no detectable C3 in the serum of the affected dogs, and there is no evidence of an inhibitor of C3 in the serum. The C3 deficiency appears to be transmitted as an autosomal recessive trait.

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Year:  1981        PMID： 7233211     DOI： 10.1126/science.7233211

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  10 in total

Review 1.  The role of complement in the acquired immune response.

Authors:  C H Nielsen; E M Fischer; R G Leslie
Journal:  Immunology       Date:  2000-05       Impact factor: 7.397

2.  From caveman companion to medical innovator: genomic insights into the origin and evolution of domestic dogs.

Authors:  Heidi G Parker; Samuel F Gilbert
Journal:  Adv Genomics Genet       Date:  2015-06-12

Review 3.  Animal models of inherited complement deficiency.

Authors:  S Linton
Journal:  Mol Biotechnol       Date:  2001-06       Impact factor: 2.695

4.  Serum complement component C3 levels in cattle: genetic influence and association with total haemolytic activity.

Authors:  M Syed; O Lie; H Solbu
Journal:  Acta Vet Scand       Date:  1986       Impact factor: 1.695

5.  Hereditary C3 hypocomplementemia in the rabbit.

Authors:  M Komatsu; K Yamamoto; Y Nakano; M Nakazawa; A Ozawa; H Mikami; M Tomita; S Migita
Journal:  Immunology       Date:  1988-07       Impact factor: 7.397

6.  Hereditary canine spinal muscular atrophy: canine motor neuron disease.

Authors:  L C Cork; D L Price; J W Griffin; G H Sack
Journal:  Can J Vet Res       Date:  1990-01       Impact factor: 1.310

Review 7.  Structure and expression of the C3 gene.

Authors:  G Fey; H Domdey; K Wiebauer; A S Whitehead; K Odink
Journal:  Springer Semin Immunopathol       Date:  1983

8.  Gene responsible for deficient activity of the beta subunit of C8, the eighth component of complement, is located on mouse chromosome 4.

Authors:  S Tanaka; T Suzuki; M Sakaizumi; Y Harada; Y Matsushima; N Miyashita; Y Fukumori; S Inai; K Moriwaki; H Yonekawa
Journal:  Immunogenetics       Date:  1991       Impact factor: 2.846

9.  Generation of complement protein C3 deficient pigs by CRISPR/Cas9-mediated gene targeting.

Authors:  Wei Zhang; Guan Wang; Ying Wang; Yong Jin; Lihua Zhao; Qiang Xiong; Lining Zhang; Lisha Mou; Rongfeng Li; Haiyuan Yang; Yifan Dai
Journal:  Sci Rep       Date:  2017-07-10       Impact factor: 4.379

10.  The third component of complement protects against Escherichia coli endotoxin-induced shock and multiple organ failure.

Authors:  Z M Quezado; W D Hoffman; J A Winkelstein; I Yatsiv; C A Koev; L C Cork; R J Elin; P Q Eichacker; C Natanson
Journal:  J Exp Med       Date:  1994-02-01       Impact factor: 14.307
  10 in total

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