Bilateral primary malignant neoplasms of the maxillary sinus: report of a case and statistical analysis of the reports in Japan.

Although double primary malignant neoplasms of bilateral maxillary sinuses wee regraded as extremely rare, there have been 50 patients described in Japan since 1937. Among them only eight cases showed the histologic distinction between both sides. A 64-year-old man with double primary carcinomas had a mucoepidermoid carcinoma of the left maxillary sinus and a papillary adenocarcinoma of the right one with an interval of three years. He was treated with a combination of surgery, radiotherapy and regional chemotherapy. The histologic combination of these tumors could not be found so far. The advantage of this combination treatment for the carcinoma of the maxillary sinus is stressed.