Literature DB >> 7228952

High-performance liquid chromatographic determination of penicillamine in whole blood, plasma, and urine.

R F Bergstrom, D R Kay, J G Wagner.   

Abstract

A high-performance liquid chromatographic method for the determination of penicillamine in plasma, whole blood, and urine samples is described. The method uses a commercially available electrochemical detector at a potential of +0.1 V versus the Ag/AgCl reference electrode. This method is selective and sensitive for sulfhydryl compounds. The chromatography separates penicillamine from other endogenous sulfhydryl compounds with a limit of detection for penicillamine in biological samples of ca. 10(07) M.

Entities:  

Mesh：

Substances：

Year:  1981        PMID： 7228952     DOI： 10.1016/s0378-4347(00)84145-6

Source DB:  PubMed          Journal:  J Chromatogr


  4 in total

Review 1.  Clinical pharmacokinetics of D-penicillamine.

Authors:  P Netter; B Bannwarth; P Péré; A Nicolas
Journal:  Clin Pharmacokinet       Date:  1987-11       Impact factor: 6.447

2.  Selective detection of endogenous thiols using microchip-based flow analysis and mercury/gold amalgam microelectrodes.

Authors:  Nicholas G Batz; R Scott Martin
Journal:  Analyst       Date:  2008-10-29       Impact factor: 4.616

3.  The pharmacokinetics of penicillamine in a female mongrel dog.

Authors:  R F Bergstrom; R D Kay; J G Wagner
Journal:  J Pharmacokinet Biopharm       Date:  1981-10

4.  D-penicillamine metabolism in an in-vivo model of inflamed synovium.

Authors:  D A Joyce; M J Forrest; P M Brooks
Journal:  Agents Actions       Date:  1988-12
  4 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.