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Literature DB >> 7228354

Suppression of human lymphocyte migration by PGE2.

Abstract

Prostaglandin (PG) E2 markedly inhibits casein- and C5a-stimulated lymphocyte migration in a concentration-dependent manner. Inhibition is observed with as low as 10(-9) M PGE2 and requires that PGE2 be present during cell locomotion. Studies with PGE1, PGF1 alpha, PGF2 alpha and PGA1 indicate that only PGE1 and PGE2 inhibit lymphocyte migration. These studies indicate that PGE2 may play a role in the regulation of the immune response at the level of lymphocyte locomotion.

Entities: Chemical Species

Mesh：

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Year: 1981 PMID： 7228354 DOI： 10.1007/bf00910782

Source DB: PubMed Journal: Inflammation ISSN： 0360-3997 Impact factor: 4.092

18 in total

1. Modulation of human neutrophil chemotactic responses by cyclic 3',5'-guanosine monophosphate and cyclic 3',5'-adenosine monophosphate.

Authors: H R Hill; R D Estensen; P G Quie; N A Hogan; N D Goldberg
Journal: Metabolism Date: 1975-03 Impact factor: 8.694

2. A chemotactic role for prostaglandins released from polymorphonuclear leucocytes during phagocytosis.

Authors: G A Higgs; E McCall; L J Youlten
Journal: Br J Pharmacol Date: 1975-04 Impact factor: 8.739

3. Locomotion of human lymphoid cells. I. Effect of culture and con A on T and non-T lymphocytes.

Authors: G J O'Neill; D M Parrott
Journal: Cell Immunol Date: 1977-10 Impact factor: 4.868

4. Cytochemical identification of monocytes and granulocytes.

Authors: L T Yam; C Y Li; W H Crosby
Journal: Am J Clin Pathol Date: 1971-03 Impact factor: 2.493

5. Studies of cell subpopulations mediating mitogen hyporesponsiveness in patients with Hodgkin's disease.

Authors: W L Sibbitt; A D Bankhurst; R C Williams
Journal: J Clin Invest Date: 1978-01 Impact factor: 14.808

6. Enhancement of human neutrophil migration by prostaglandin E2.

Authors: D E Van Epps; A Wiik; M L Garcia; R C Williams
Journal: Cell Immunol Date: 1978-04 Impact factor: 4.868

7. The role of cyclic AMP in the chemotactic responsiveness and spontaneous motility of rabbit peritoneal neutrophils. The inhibition of neutrophil movement and the elevation of cyclic AMP levels by catecholamines, prostaglandins, theophylline and cholera toxin.

Authors: I Rivkin; J Rosenblatt; E L Becker
Journal: J Immunol Date: 1975-10 Impact factor: 5.422

8. The in vitro effects of histamine and metiamide on neutrophil motility and their relationship to intracellular cyclic nucleotide levels.

Authors: R Anderson; A Glover; A R Rabson
Journal: J Immunol Date: 1977-05 Impact factor: 5.422

6. Evidence for the involvement of interleukin 10 in the differential deactivation of murine peritoneal macrophages by prostaglandin E2.

Authors: G Strassmann; V Patil-Koota; F Finkelman; M Fong; T Kambayashi
Journal: J Exp Med Date: 1994-12-01 Impact factor: 14.307

6 in total

Suppression of human lymphocyte migration by PGE2.

1. Modulation of human neutrophil chemotactic responses by cyclic 3',5'-guanosine monophosphate and cyclic 3',5'-adenosine monophosphate.

2. A chemotactic role for prostaglandins released from polymorphonuclear leucocytes during phagocytosis.

3. Locomotion of human lymphoid cells. I. Effect of culture and con A on T and non-T lymphocytes.

4. Cytochemical identification of monocytes and granulocytes.

5. Studies of cell subpopulations mediating mitogen hyporesponsiveness in patients with Hodgkin's disease.

6. Enhancement of human neutrophil migration by prostaglandin E2.

7. The role of cyclic AMP in the chemotactic responsiveness and spontaneous motility of rabbit peritoneal neutrophils. The inhibition of neutrophil movement and the elevation of cyclic AMP levels by catecholamines, prostaglandins, theophylline and cholera toxin.

8. The in vitro effects of histamine and metiamide on neutrophil motility and their relationship to intracellular cyclic nucleotide levels.

9. Chemotaxis of rat lymphocytes.

10. Prostaglandin suppression of mitogen-stimulated lymphocytes in vitro. Changes with mitogen dose and preincubation.

1. Prostaglandin E₂ Inhibits the Ability of Neutrophils to Kill Listeria monocytogenes.

2. Effect of leukotriene B4 and prostaglandin E2 on the adhesion of lymphocytes to endothelial cells.

3. Decreased T lymphocyte migration in patients with malignancy mediated by a suppressor cell population.

Review 4. Regulation of the immune response by prostaglandins.

Review 5. Polyunsaturated Fatty Acid-derived lipid mediators and T cell function.

6. Evidence for the involvement of interleukin 10 in the differential deactivation of murine peritoneal macrophages by prostaglandin E2.