| Literature DB >> 722713 |
M J Fasco, P P Dymerski, J D Wos, L S Kaminsky.
Abstract
The metabolism of the clinically utilized, anticoagulant warfarin [4-hydroxy-3-(3-oxo-1-phenylbutyl)-2H-1-benzopyran-2-one] by rat liver microsomes has been investigated. The structure of a new warfarin metabolite [4-hydroxy-3-(3-oxo-1-phenyl-1-butenyl)-2H-1-benzopyran-2-one] (dehydrowarfarin) has been determined by mass spectral comparison with the chemically synthesized compound. The formation of dehydrowarfarin is catalyzed by cytochrome P-450 and is unusual in that the final product is effectively dehydrogenated warfarin.Entities:
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Year: 1978 PMID： 722713 DOI： 10.1021/jm00208a009
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446