Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Formation of mutagens in cooked foods. III. Isolation of a potent mutagen from beef.

Literature DB >> 7226149

Formation of mutagens in cooked foods. III. Isolation of a potent mutagen from beef.

N E Spingarn, H Kasai, L L Vuolo, S Nishimura, Z Yamaizumi, T Sugimura, T Matsushima, J H Weisburger.

Abstract

The major mutagenic component of fried beef has been isolated using a series of chromatographic steps. The pure compound has been analyzed by low and high resolution mass spectroscopy and nuclear magnetic resonance spectroscopy. The results indicate that the molecular weight of this extremely mutagenic compound is 198, with an elemental composition of C11H10N4. The compound is different from the known mutagenic pyrolysis products of amino acids or proteins.

Entities: Species

Mesh：

Substances：
Mutagens

Year: 1980 PMID： 7226149 DOI： 10.1016/0304-3835(80)90084-1

Source DB: PubMed Journal: Cancer Lett ISSN： 0304-3835 Impact factor: 8.679

Keyword Cloud
Cited

8 in total

1. Nutrition and cancer--on the mechanisms bearing on causes of cancer of the colon, breast, prostate, and stomach.

Authors: J H Weisburger; B S Reddy; P Hill; L A Cohen; E L Wynder; N E Spingarn
Journal: Bull N Y Acad Med Date: 1980-10

2. Comparison of the reactivity of B-DNA and Z-DNA with two isosteric chemical carcinogens: 2-N,N-acetoxyacetylaminofluorene and 3-N,N-acetoxyacetylamino-4,6-dimethyldipyrido-[1,2-a:3',2' -d] imidazole.

Authors: L Marrot; E Hebert; G Saint-Ruf; M Leng
Journal: Nucleic Acids Res Date: 1987-07-24 Impact factor: 16.971

3. Conformational changes induced in DNA by the in vitro reaction with the mutagenic amine: 3-N,N-acetoxyacetylamino-4,6-dimethyldipyrido (1,2-a: 3', 2'-d) imidazole.

Authors: E Hébert; B Loukakou; G Saint-Ruf; M Leng
Journal: Nucleic Acids Res Date: 1984-11-26 Impact factor: 16.971

Formation of mutagens in cooked foods. III. Isolation of a potent mutagen from beef.

1. Nutrition and cancer--on the mechanisms bearing on causes of cancer of the colon, breast, prostate, and stomach.

2. Comparison of the reactivity of B-DNA and Z-DNA with two isosteric chemical carcinogens: 2-N,N-acetoxyacetylaminofluorene and 3-N,N-acetoxyacetylamino-4,6-dimethyldipyrido-[1,2-a:3',2' -d] imidazole.

3. Conformational changes induced in DNA by the in vitro reaction with the mutagenic amine: 3-N,N-acetoxyacetylamino-4,6-dimethyldipyrido (1,2-a: 3', 2'-d) imidazole.

Review 4. [The decomposition of reducing sugars and amines in the Maillard reaction].

5. Heterocyclic amines: occurrence and prevention in cooked food.

6. Animal food intake and cooking methods in relation to endometrial cancer risk in Shanghai.

Review 7. Metabolism and biomarkers of heterocyclic aromatic amines in humans.

8. Use of blue cotton for detection of mutagenicity in human feces excreted after ingestion of cooked meat.