| Literature DB >> 7226147 |
E E McConnell, R E Wilson, J A Moore, J K Haseman.
Abstract
Weanling male and female F 344 rats were given various doses of 1,2-dimethylhydrazine (DMH) or methylazoxymethyl acetate (MAMAc), and were then held for 46-64 weeks in an effort to determine a dose response and establish a dose level which would produce a low level of intestinal neoplasia with a minimal number of tumors in other organs. DMH proved superior to MAM in this respect, although liver lesions were still observed with both compounds at the lowest carcinogenic intestinal dose.Entities:
Mesh：
Substances：
Year: 1980 PMID： 7226147 DOI： 10.1016/0304-3835(80)90013-0
Source DB: PubMed Journal: Cancer Lett ISSN： 0304-3835 Impact factor: 8.679