Literature DB >> 7225714

The anticoagulant activity of dermatan sulphates: evidence against the involvement of antithrombin III.

G Kindness, W F Long, F B Williamson.   

Abstract

Anticoagulant activity of dermatan sulphates is unaffected by antiserum specific for antithrombin III (AT III) unless the glycosaminoglycan preparation contains demonstrable heparin. 2 Only dermatan sulphate preparations of considerable heparin content potentiate AT III inhibition of thrombin, factor Xa and plasmin. 3 These data suggest that dermatan sulphates exert anticoagulant activity which, unlike that of heparin, is largely or totally independent of AT III.

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Year:  1981        PMID： 7225714      PMCID： PMC2071556          DOI： 10.1111/j.1476-5381.1981.tb09108.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  21 in total

1.  The action of antithrombin III on plasmin and activators of plasminogen.

Authors:  G P Crawford; D Ogston
Journal:  Biochim Biophys Acta       Date:  1975-05-23

2.  Distribution of acidic glycosaminoglycans in the intima, media and adventitia of bovine aorta and their anticoagulant properties.

Authors:  K Murata; K Nakazawa; A Hamai
Journal:  Atherosclerosis       Date:  1975 Jan-Feb       Impact factor: 5.162

3.  The anticoagulant effect of heparan sulfate and dermatan sulfate.

Authors:  A N Teien; U Abildgaard; M Höök
Journal:  Thromb Res       Date:  1976-06       Impact factor: 3.944

Review 4.  Glycosaminoglycans and their binding to biological macromolecules.

Authors:  U Lindahl; M Höök
Journal:  Annu Rev Biochem       Date:  1978       Impact factor: 23.643

5.  The inhibition of human plasmin by human antithrombin-heparin cofactor.

Authors:  R F Highsmith; R D Rosenberg
Journal:  J Biol Chem       Date:  1974-07-25       Impact factor: 5.157

6.  Study of the clotting, esterase and platelet aggregating activities of thrombin, acetylated thrombin and reptilase.

Authors:  O Tangen; S Bygdeman
Journal:  Scand J Haematol       Date:  1972

7.  A heparin analogue with specific action on antithrombin III.

Authors:  D P Thomas; D A Lane; R Michalski; E A Johnson; V V Kakkar
Journal:  Lancet       Date:  1977-01-15       Impact factor: 79.321

8.  Aortic total glycosaminoglycan and dermatan sulfate changes in atherosclerotic rhesus monkeys.

Authors:  W D Wagner; B G Salisbury
Journal:  Lab Invest       Date:  1978-10       Impact factor: 5.662

9.  The copolymeric structure of dermatan sulphate produced by cultured human fibroblasts. Different distribution of iduronic acid and glucuronic acid-containing units in soluble and cell-associated glycans.

Authors:  A Malström; I Carlstedt; L Aberg; L A Fransson
Journal:  Biochem J       Date:  1975-12       Impact factor: 3.857

10.  The heterogeneity of dermatan sulfate and heparan sulfate in rat liver and a shift in the glycosaminoglycan contents in carbon tetrachloride-damaged liver.

Authors:  S Suzuki; S Suzuki; N Nakamura; T Koizumi
Journal:  Biochim Biophys Acta       Date:  1976-03-25
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  2 in total

1.  Effect of sulphated polysaccharides on the alpha 1-antitrypsin inhibition of amidolysis catalysed by coagulation cascade proteinases.

Authors:  W F Long; F B Williamson
Journal:  Br J Pharmacol       Date:  1981-06       Impact factor: 8.739

2.  Structure-activity relationships of heparin. Independence of heparin charge density and antithrombin-binding domains in thrombin inhibition by antithrombin and heparin cofactor II.

Authors:  R E Hurst; M C Poon; M J Griffith
Journal:  J Clin Invest       Date:  1983-09       Impact factor: 14.808
  2 in total

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