Literature DB >> 7225712

Spurious effects of commercial preparations of oxytocin on the isolated vas deferens of the rat.

J H Botting.   

Abstract

1 The inhibitory effect of a commercial preparation of oxytocin (Syntocinon) was studied on the isolated vas deferens of the rat. 2 The inhibition of contractions to agonists and to field stimulation obtained were mimicked by appropriate dilutions of chlorbutol, a preservative present in Syntocinon. 3 Preservative-free synthetic oxytocin had no inhibitory effect on the tissue and slightly potentiated contractions evoked by field stimulation. 4 It is concluded that inhibitory effects of Syntocinon on the vas deferens are due to chlorbutol, not oxytocin.

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Year:  1981        PMID： 7225712      PMCID： PMC2071552          DOI： 10.1111/j.1476-5381.1981.tb09111.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  5 in total

1.  ANTIARRHYTHMIC AND CARDIOVASCULAR EFFECTS OF SYNTHETIC OXYTOCIN.

Authors:  R L KATZ
Journal:  Anesthesiology       Date:  1964 Sep-Oct       Impact factor: 7.892

2.  The action of commercial preparations of oxytocin and vasopressin on the smooth muscle of the gut.

Authors:  J H Botting; D G Manley
Journal:  J Pharm Pharmacol       Date:  1967-01       Impact factor: 3.765

3.  Effect of magnesium on posterior pituitary hormone action on vascular smooth muscle.

Authors:  A V Somlyo; C Y Woo; A P Somlyo
Journal:  Am J Physiol       Date:  1966-04

4.  Effects of oxytocin on the isolated vas deferens of the rat.

Authors:  J V Beneit; A Hidalgo; J L Tamargo
Journal:  Br J Pharmacol       Date:  1980-07       Impact factor: 8.739

5.  The effect of indomethacin on the release of prostaglandin E2 and acetylcholine from guinea-pig isolated ileum at rest and during field stimulation.

Authors:  J H Botting; R Salzmann
Journal:  Br J Pharmacol       Date:  1974-01       Impact factor: 8.739
  5 in total

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