Literature DB >> 7225539

The use of stable isotopes to prove the saturable first-pass effect of methoxsalen.

J Schmid, A Prox, H Zipp, F W Koss.   

Abstract

Methoxsalen, administered orally shows a strong, albeit saturable first-pass effect, as demonstrated by classical dose linearity testing and by a new method, using stable isotopes and gas chromatographic mass spectrometric analysis. The therapeutic consequences of the first-pass effect are discussed.

Entities:  

Mesh：

Substances：

Year:  1980        PMID： 7225539     DOI： 10.1002/bms.1200071123

Source DB:  PubMed          Journal:  Biomed Mass Spectrom        ISSN： 0306-042X


  8 in total

1.  Bioavailability estimation by semisimultaneous drug administration: a Monte Carlo simulation study.

Authors:  M O Karlsson; U Bredberg
Journal:  J Pharmacokinet Biopharm       Date:  1990-04

2.  Concurrent intravenous administration of a labeled tracer to determine the oral bioavailability of a drug exhibiting Michaelis-Menten metabolism.

Authors:  G M Rubin; J A Waschek; S M Pond; D J Effeney; T N Tozer
Journal:  J Pharmacokinet Biopharm       Date:  1987-12

3.  Estimation of bioavailability on a single occasion after semisimultaneous drug administration.

Authors:  M O Karlsson; U Bredberg
Journal:  Pharm Res       Date:  1989-09       Impact factor: 4.200

Review 4.  Application of stable labelled drugs in clinical pharmacokinetic investigations.

Authors:  M Eichelbaum; G E von Unruh; A Somogyi
Journal:  Clin Pharmacokinet       Date:  1982 Nov-Dec       Impact factor: 6.447

Review 5.  5-Methoxypsoralen. A review of its effects in psoriasis and vitiligo.

Authors:  W McNeely; K L Goa
Journal:  Drugs       Date:  1998-10       Impact factor: 9.546

Review 6.  Clinical pharmacokinetics of methoxsalen and other psoralens.

Authors:  F A de Wolff; T V Thomas
Journal:  Clin Pharmacokinet       Date:  1986 Jan-Feb       Impact factor: 6.447

7.  The pharmacokinetics of 8-methoxypsoralen following i.v. administration in humans.

Authors:  V Billard; P L Gambus; J Barr; C F Minto; L Corash; J W Tessman; J L Stickney; S L Shafer
Journal:  Br J Clin Pharmacol       Date:  1995-10       Impact factor: 4.335

8.  Food-induced increase in bioavailability of 5-methoxypsoralen.

Authors:  H Ehrsson; I Wallin; A M Ros; S Eksborg; M Berg
Journal:  Eur J Clin Pharmacol       Date:  1994       Impact factor: 2.953
  8 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.