Literature DB >> 7225483

Use of THA in treatment of Alzheimer-like dementia: pilot study in twelve patients.

W K Summers, J O Viesselman, G M Marsh, K Candelora.   

Abstract

THA, a centrally acting anticholinesterase, was given intravenously in varying doses to 12 unselected cases of Alzheimer-like senile dementia. Significant improvement in memory testing occurred in 6 of 12 subjects; 9 of 12 improved in clinical staging. Analysis of results with respect to staging of dementia revealed that the degree of improvement was inversely related to the severity of dementia. Statistical analysis of these data by the Friedman test is detailed.

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Year:  1981        PMID: 7225483

Source DB:  PubMed          Journal:  Biol Psychiatry        ISSN: 0006-3223            Impact factor:   13.382


  22 in total

1.  Optimism in the treatment of Alzheimer's disease.

Authors:  L Carrier
Journal:  J Psychiatry Neurosci       Date:  1999-11       Impact factor: 6.186

Review 2.  Behavioral screening for cognition enhancers: from indiscriminate to valid testing: Part I.

Authors:  M Sarter; J Hagan; P Dudchenko
Journal:  Psychopharmacology (Berl)       Date:  1992       Impact factor: 4.530

Review 3.  Critical review of clinical trials in senile dementia--II.

Authors:  J M Orgogozo; R Spiegel
Journal:  Postgrad Med J       Date:  1987-05       Impact factor: 2.401

4.  Tetrahydroaminoacridine (tacrine) stimulates neurosecretion at mammalian motor endplates.

Authors:  S Thesleff; L C Sellin; S Tågerud
Journal:  Br J Pharmacol       Date:  1990-07       Impact factor: 8.739

Review 5.  Prescribing CNS drugs for elderly patients.

Authors:  K Ghose
Journal:  Drugs Aging       Date:  1994-04       Impact factor: 3.923

6.  Cholinergic system and constructional praxis: a further study of physostigmine in Alzheimer's disease.

Authors:  O Muramoto; M Sugishita; K Ando
Journal:  J Neurol Neurosurg Psychiatry       Date:  1984-05       Impact factor: 10.154

7.  Effects of the centrally acting cholinesterase inhibitors tetrahydroaminoacridine and E2020 on the basal concentration of extracellular acetylcholine in the hippocampus of freely moving rats.

Authors:  K Kawashima; A Sato; M Yoshizawa; T Fujii; K Fujimoto; T Suzuki
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1994-11       Impact factor: 3.000

8.  The effectiveness of amiridin in senile dementia of the Alzheimer's type.

Authors:  E E Bukatina; I V Grigor'eva; E I Sokol'chik
Journal:  Neurosci Behav Physiol       Date:  1993 Jan-Feb

Review 9.  Diagnostic and pharmacological approaches in Alzheimer's disease.

Authors:  C Hermann; R G Stern; M F Losonzcy; S Jaff; M Davidson
Journal:  Drugs Aging       Date:  1991-03       Impact factor: 3.923

10.  Distribution of tacrine across the blood-brain barrier in awake, freely moving rats using in vivo microdialysis sampling.

Authors:  M Telting-Diaz; C E Lunte
Journal:  Pharm Res       Date:  1993-01       Impact factor: 4.200

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