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Literature DB >> 7225080

A new locus regulating the expression of the Ldh-2 gene in mouse liver.

Abstract

Patterns of lactate dehydrogenase (LDH) isozymes of tissues from various mouse strains were examined. An interstrain polymorphism for LDH isozymes of liver was established. One phenotype (CBA/Lac and AKR/J mice) yielded a five-banded LDH pattern, another phenotype (DBA/1J, DBA/2J, C57BL/6J and C3H/He) showed a three-banded one. Immunochemical evidence was obtained indicating that differences in the LDH pattern are mainly due to different contents of the B subunit of LDH. Linkage tests indicated that the locus Ldr-2 determining the amounts of the LDH B subunit in mouse liver tissue is located in chromosome 6, 19 + or - 4.1 cm away from the earlier described Ldr-1 locus. The effect of locus Ldr-2 is strictly tissue-specific; it is manifest only on days 6-8 after birth.

Entities: Gene Species

Mesh：

Substances：

Year: 1980 PMID： 7225080 DOI： 10.1007/bf00500133

Source DB: PubMed Journal: Biochem Genet ISSN： 0006-2928 Impact factor: 1.890

17 in total

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Journal: Cytogenet Cell Genet Date: 1978

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6 in total

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Journal: Mamm Genome Date: 1992 Impact factor: 2.957

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Journal: J Mol Evol Date: 1986 Impact factor: 2.395

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Journal: Mol Gen Genet Date: 1985