Literature DB >> 7224511

Nature of blood-labyrinth barrier in experimental conditions.

S K Juhn, L P Rybak, S Prado.   

Abstract

The blood-labyrinth barrier is concept that has evolved based on marked difference in chemical composition between perilymph and blood. Studies reported here have been designed to manipulate physiologic, metabolic, and pharmacologic conditions in experimental animals in order to determine the characteristics of this regulatory mechanisms. Tracer studies of uptake of sodium, calcium, and albumin from blood into perilymph showed that these substances penetrate into inner ear fluids quite slowly. Injections of ototoxic substances (kanamycin, furosemide) show limited transport of these agents into perilymph. Administration of an osmotic agent (urea) resulted in a parallel but delayed elevation of perilymph concentration. The possible role of a alteration of blood-labyrinth barrier in inner ear disorders has been discussed.

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Year:  1981        PMID： 7224511     DOI： 10.1177/000348948109000208

Source DB:  PubMed          Journal:  Ann Otol Rhinol Laryngol        ISSN： 0003-4894            Impact factor:   1.547


  25 in total

1.  Perivascular-resident macrophage-like melanocytes in the inner ear are essential for the integrity of the intrastrial fluid-blood barrier.

Authors:  Wenjing Zhang; Min Dai; Anders Fridberger; Ahmed Hassan; Jacqueline Degagne; Lingling Neng; Fei Zhang; Wenxuan He; Tianying Ren; Dennis Trune; Manfred Auer; Xiaorui Shi
Journal:  Proc Natl Acad Sci U S A       Date:  2012-06-11       Impact factor: 11.205

2.  Kinetic experiments with radionuclides concerning the perilymph-blood barrier in a guinea pig model.

Authors:  W K Jung; G Gattaz; F J Schön
Journal:  Arch Otorhinolaryngol       Date:  1989

3.  IL-10/HMOX1 signaling modulates cochlear inflammation via negative regulation of MCP-1/CCL2 expression in cochlear fibrocytes.

Authors:  Jeong-Im Woo; Sung-Hee Kil; Sejo Oh; Yoo-Jin Lee; Raekil Park; David J Lim; Sung K Moon
Journal:  J Immunol       Date:  2015-03-16       Impact factor: 5.422

4.  DC potentials of the lateral wall of the scala media.

Authors:  R Urquiza; A Diez de los Rios
Journal:  Arch Otorhinolaryngol       Date:  1987

Review 5.  Delivery of therapeutics to the inner ear: The challenge of the blood-labyrinth barrier.

Authors:  Sophie Nyberg; N Joan Abbott; Xiaorui Shi; Peter S Steyger; Alain Dabdoub
Journal:  Sci Transl Med       Date:  2019-03-06       Impact factor: 17.956

Review 6.  Organic acid transport into the cochlear perilymph.

Authors:  L P Rybak
Journal:  Arch Otorhinolaryngol       Date:  1987

7.  Localized cell and drug delivery for auditory prostheses.

Authors:  Jeffrey L Hendricks; Jennifer A Chikar; Mark A Crumling; Yehoash Raphael; David C Martin
Journal:  Hear Res       Date:  2008-06-07       Impact factor: 3.208

8.  Bi-phasic intensity-dependent opioid-mediated neural amplitude changes in the chinchilla cochlea: partial blockade by an N-Methyl-D-Aspartate (NMDA)-receptor antagonist.

Authors:  Tony L Sahley; David J Anderson; Cheryl L Chernicky
Journal:  Eur J Pharmacol       Date:  2007-10-25       Impact factor: 4.432

9.  Proinflammatory cytokine expression in the endolymphatic sac during inner ear inflammation.

Authors:  Hitoshi Satoh; Gary S Firestein; Peter B Billings; Jeffrey P Harris; Elizabeth M Keithley
Journal:  J Assoc Res Otolaryngol       Date:  2003-06

10.  The role of inflammatory mediators in the pathogenesis of otitis media and sequelae.

Authors:  Steven K Juhn; Min-Kyo Jung; Mark D Hoffman; Brian R Drew; Diego A Preciado; Nicholas J Sausen; Timothy T K Jung; Bo Hyung Kim; Sang-Yoo Park; Jizhen Lin; Frank G Ondrey; David R Mains; Tina Huang
Journal:  Clin Exp Otorhinolaryngol       Date:  2008-09-30       Impact factor: 3.372
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