Literature DB >> 7223428

Aneuploidy as a marker for carcinoma-in-situ of the testis.

J Müller, N E Skakkeboek, C Lundsteen.   

Abstract

A microspectrophotometric study of the DNA content of carcinoma-in-situ germ cells in the testes of eight infertile men revealed an aneuploid DNA distribution pattern. The results support the assumption that carcinoma-in-situ germ cells are of a malignant nature. The findings also indicate that the DNA content can be used to discriminate between carcinoma-in-situ germ cells and spermatogonia.

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Year:  1981        PMID： 7223428     DOI： 10.1111/j.1699-0463.1981.tb00190.x

Source DB:  PubMed          Journal:  Acta Pathol Microbiol Scand A        ISSN： 0365-4184


  4 in total

1.  Carcinoma in situ of the testis. Detection of malignant germ cells in seminal fluid by means of in situ hybridization.

Authors:  A Giwercman; A H Hopman; F C Ramaekers; N E Skakkebaek
Journal:  Am J Pathol       Date:  1990-03       Impact factor: 4.307

2.  Ki-A10, a germ cell nuclear antigen retained in a subset of germ cell-derived tumors.

Authors:  P Rudolph; U Kellner; D Schmidt; V Kirchner; A Talerman; D Harms; R Parwaresch
Journal:  Am J Pathol       Date:  1999-03       Impact factor: 4.307

3.  Analysis of gene expression profiles of microdissected cell populations indicates that testicular carcinoma in situ is an arrested gonocyte.

Authors:  Si Brask Sonne; Kristian Almstrup; Marlene Dalgaard; Agnieszka Sierakowska Juncker; Daniel Edsgard; Ludmila Ruban; Neil J Harrison; Christian Schwager; Amir Abdollahi; Peter E Huber; Søren Brunak; Lise Mette Gjerdrum; Harry D Moore; Peter W Andrews; Niels E Skakkebaek; Ewa Rajpert-De Meyts; Henrik Leffers
Journal:  Cancer Res       Date:  2009-06-02       Impact factor: 12.701

4.  Heterogeneity of expression of immunohistochemical tumour markers in testicular carcinoma in situ: pathogenetic relevance.

Authors:  E Rajpert-De Meyts; M Kvist; N E Skakkebaek
Journal:  Virchows Arch       Date:  1996-06       Impact factor: 4.064
  4 in total

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