Literature DB >> 7223376

Retinal amacrine cell involvement in Tay-Sachs disease.

K Nagashima, F Kikuchi, Y Suzuki, T Abe.   

Abstract

Ultrastructural study of the retina from a patient with Tay-Sachs disease disclosed that amacrine cells as well as ganglion cells were loaded with numerous membranous cytoplasmic bodies, suggesting an accumulation of GM2 ganglioside, whereas the horizontal cells, bipolar cells, and photoreceptor cells were intact. Chromatography of lipids from the retina showed a prominent spot of GM2 ganglioside. These facts suggest that lipid metabolism in amacrine cells may be different from that in other retinal cells.

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Year:  1981        PMID： 7223376     DOI： 10.1007/bf00690376

Source DB:  PubMed          Journal:  Acta Neuropathol        ISSN： 0001-6322            Impact factor:   17.088


  19 in total

1.  The amacrine cell.

Authors:  R Y Chan; K Naka
Journal:  Vision Res       Date:  1976       Impact factor: 1.886

Review 2.  Retinal gangliosides: composition, evolution with age. Biosynthetic and metabolic approaches.

Authors:  H Dreyfus; P F Urban; S Harth; A Preti; P Mandel
Journal:  Adv Exp Med Biol       Date:  1976       Impact factor: 2.622

3.  Enkephalin-containing amacrine cells in the avian retina: immunohistochemical localization.

Authors:  N Brecha; H J Karten; C Laverack
Journal:  Proc Natl Acad Sci U S A       Date:  1979-06       Impact factor: 11.205

4.  Ocular pathology of GM2 gangliosidosis--Type 2 (Sandhoff's disease).

Authors:  A Garner
Journal:  Br J Ophthalmol       Date:  1973-07       Impact factor: 4.638

5.  Gangliosides of human, bovine and rabbit retina.

Authors:  M Holm; J E Månsson; M T Vanier; L Svennerholm
Journal:  Biochim Biophys Acta       Date:  1972-10-05

6.  The sphingolipidoses and the eye.

Authors:  D G Cogan; T Kuwabara
Journal:  Arch Ophthalmol       Date:  1968-04

7.  Ultrastructure of the retina in Tay-Sach's disease.

Authors:  R B Harcourt; R H Dobbs
Journal:  Br J Ophthalmol       Date:  1968-12       Impact factor: 4.638

8.  The inner plexiform layer in the retina of the cat: electron microscopic observations.

Authors:  H Kolb
Journal:  J Neurocytol       Date:  1979-06

9.  The gamma-aminobutyric acid system in rabbit retina: localization by immunocytochemistry and autoradiography.

Authors:  C Brandon; D M Lam; J Y Wu
Journal:  Proc Natl Acad Sci U S A       Date:  1979-07       Impact factor: 11.205

10.  Ocular pathology of bovine GM1 gangliosidosis.

Authors:  B J Sheahan; W J Donnelly; T D Grimes
Journal:  Acta Neuropathol       Date:  1978-02-20       Impact factor: 17.088
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  3 in total

1.  Natural history of infantile G(M2) gangliosidosis.

Authors:  Annette E Bley; Ourania A Giannikopoulos; Doug Hayden; Kim Kubilus; Cynthia J Tifft; Florian S Eichler
Journal:  Pediatrics       Date:  2011-10-24       Impact factor: 7.124

2.  Amacrine and horizontal cell dysfunction in adult ceroid-lipofuscinosis (Kufs disease) and anatomical correlates in the ovine model.

Authors:  D Armstrong; M Benedetto; D Samuelson
Journal:  Int Ophthalmol       Date:  1985-04       Impact factor: 2.031

3.  Spinal ganglia and peripheral nerves from a patent with Tay-Sachs disease. Morphological and ganglioside studies.

Authors:  T Abe; K Ogawa; H Fuziwara; K Urayama; K Nagashima
Journal:  Acta Neuropathol       Date:  1985       Impact factor: 17.088
  3 in total

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