Literature DB >> 7223367

Dose-dependent effects of peroral dimethylformamide administration on rat brain.

H Savolainen.   

Abstract

Three-month-old Wistar rats were given dimethylformamide in their drinking water at three concentrations. Succinate dehydrogenase activity decreased at the two higher doses in brain after 2 or 7 weeks. Decreased glutathione concentration occurred at the highest dose. Cerebral azoreductase activity was below the control range after 7 weeks at all doses. Glial cell succinate dehydrogenase activity was below the control range in all animals. No qualitative changes in the spinal cord axon protein composition were detected. It is postulated that formic acid generated in the dimethylformamide metabolism might have led to a significant derangement of cerebral energy metabolism.

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Year:  1981        PMID： 7223367     DOI： 10.1007/bf00688028

Source DB:  PubMed          Journal:  Acta Neuropathol        ISSN： 0001-6322            Impact factor:   17.088


  33 in total

1.  Toxicological investigations on dimethylformamide.

Authors:  W MASSMANN
Journal:  Br J Ind Med       Date:  1956-01

2.  Molecular weight estimation of polypeptide chains by electrophoresis in SDS-polyacrylamide gels.

Authors:  A L Shapiro; E Viñuela; J V Maizel
Journal:  Biochem Biophys Res Commun       Date:  1967-09-07       Impact factor: 3.575

3.  Glial cell toxicity of ethyleneglycol monomethylether vapor.

Authors:  H Savolainen
Journal:  Environ Res       Date:  1980-08       Impact factor: 6.498

4.  Induction of rat liver cytosol methyl red azo-reductase by 3-methylcholanthrene assayed by a sensitive fluorometric method.

Authors:  M T Huang; G T Miwa; A Y Lu
Journal:  Biochem Biophys Res Commun       Date:  1978-08-29       Impact factor: 3.575

Review 5.  Inhibitors of respiration at energy-coupling site 2 of the respiratory chain.

Authors:  J S Rieske
Journal:  Pharmacol Ther       Date:  1980       Impact factor: 12.310

6.  Sequelae of carbon monoxide-induced hypoxia in the rat.

Authors:  J H Petajan; S C Packham; D B Frens; B G Dinger
Journal:  Arch Neurol       Date:  1976-03

7.  Glutathione and ascorbate during ischemia and postischemic reperfusion in rat brain.

Authors:  A J Cooper; W A Pulsinelli; T E Duffy
Journal:  J Neurochem       Date:  1980-11       Impact factor: 5.372

8.  Monomethylformamide levels in human urine after repetitive exposure to dimethylformamide vapor.

Authors:  N D Krivanek; M McLaughlin; W E Fayweather
Journal:  J Occup Med       Date:  1978-03

9.  Toxicity of dimethylformamide (DMF) to the young female rat.

Authors:  K I Tanaka
Journal:  Int Arch Arbeitsmed       Date:  1971

10.  Effect of ischemic anoxia and barbiturate anesthesia on free radical oxidation of mitochondrial phospholipids.

Authors:  M D Majewska; J Strosznajder; J Lazarewicz
Journal:  Brain Res       Date:  1978-12-15       Impact factor: 3.252
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  1 in total

1.  Report on the Consensus Workshop on Formaldehyde.

Authors: 
Journal:  Environ Health Perspect       Date:  1984-12       Impact factor: 9.031
  1 in total

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