Literature DB >> 7222199

Effect of heat on the conversion of di-2-ethylhexyl phthalate to mono-2-ethylhexyl phthalate in human plasma.

C C Peck, D G Odom, P W Albro, D A Jess, B B Barrett.   

Abstract

Plasma di-2-ethylhexyl phthalate (DEHP), which accumulates during blood storage in plastic bags, gives rise to plasma mono-2-ethylhexyl phthalate (MEHP). This also in plasma samples awaiting analysis, which are no longer stored in plastic bags. Heating plasma samples at 60 C for 25 to 30 minutes in a water bath effectively halts conversion of DEHP to MEHP during subsequent room temperature storage for at least 100 hours. This result is consistent with the view that MEHP accumulation in plasma is due to enzymatic hydrolysis of DEHP by esterase (s) which can be heat-inactivated.

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Year:  1981        PMID: 7222199     DOI: 10.1046/j.1537-2995.1981.21281178151.x

Source DB:  PubMed          Journal:  Transfusion        ISSN: 0041-1132            Impact factor:   3.157


  5 in total

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Authors:  Flavia V Ferreira; Matías A Musumeci
Journal:  World J Microbiol Biotechnol       Date:  2021-04-26       Impact factor: 3.312

2.  A review of alternatives to di (2-ethylhexyl) phthalate-containing medical devices in the neonatal intensive care unit.

Authors:  E D S Van Vliet; E M Reitano; J S Chhabra; G P Bergen; R M Whyatt
Journal:  J Perinatol       Date:  2011-02-10       Impact factor: 2.521

3.  Phthalate-associated hypertension in premature infants: a prospective mechanistic cohort study.

Authors:  Randall Jenkins; Shane Tackitt; Ladawna Gievers; Sandra Iragorri; Kylie Sage; Tonya Cornwall; Declan O'Riordan; Jennifer Merchant; David Rozansky
Journal:  Pediatr Nephrol       Date:  2019-04-26       Impact factor: 3.714

4.  Toxic potential of the plasticizer Di(2-ethylhexyl) phthalate in the context of its disposition and metabolism in primates and man.

Authors:  C C Peck; P W Albro
Journal:  Environ Health Perspect       Date:  1982-11       Impact factor: 9.031

5.  Comparison of the short term toxicity of phthalate diesters and monoesters in sprague-dawley male rats.

Authors:  Seung Jun Kwack; Eun Young Han; Jae Seok Park; Jung Yun Bae; Il Young Ahn; Seong Kwang Lim; Dong Hyun Kim; Dong Eun Jang; Lan Choi; Hyun Jung Lim; Tae Hyung Kim; Nabanita Patra; Kui Lea Park; Hyung Sik Kim; Byung Mu Lee
Journal:  Toxicol Res       Date:  2010-03
  5 in total

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