Literature DB >> 7222098

Sister-chromatid exchanges induced in vitro by cyclophosphamide without exogenous metabolic activation in lymphocytes from three mammalian species.

D H Waalkens, H F Joosten, R D Taalman, J M Scheres, T D Yih, A Hoekstra.   

Abstract

The induction of sister-chromatid exchanges (SCEs) by cyclophosphamide (CP) in human, rat and rabbit lymphocytes was studied in vitro without exogenous metabolic activation. In contrast with published reports, CP induced SCEs in lymphocytes from all three species, indicating that cultured lymphocytes possess the metabolic capacity to convert this indirect-acting mutagen.

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Year:  1981        PMID： 7222098     DOI： 10.1016/0378-4274(81)90073-4

Source DB:  PubMed          Journal:  Toxicol Lett        ISSN： 0378-4274            Impact factor:   4.372


  2 in total

1.  Cyclophosphamide metabolism in the primary immune organs of the chick: assays of drug activation, P450 expression, and aldehyde dehydrogenase.

Authors:  R R Misra; N A Lorr; S E Bloom
Journal:  Arch Toxicol       Date:  1991       Impact factor: 5.153

2.  Ligands and Signaling of Mas-Related G Protein-Coupled Receptor-X2 in Mast Cell Activation.

Authors:  Yan-Ni Mi; Na-Na Ping; Yong-Xiao Cao
Journal:  Rev Physiol Biochem Pharmacol       Date:  2021       Impact factor: 5.545
  2 in total

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