| Literature DB >> 7222096 |
R C Murthy, R S Srivastava, S V Chandra.
Abstract
Rats were exposed to manganese (Mn) (6 mg/kg) daily for 30 days. The content of ceruloplasmin decreased significantly by 19.5% while copper (Cu) content was reduced by 27.8% in the serum of Mn-treated animals. These alterations were associated with a marked increase in the Cu content of liver and brain. The significant decrease in serum Cu and ceruloplasmin may serve as useful parameters for early diagnosis of Mn poisoning.Entities:
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Year: 1981 PMID： 7222096 DOI： 10.1016/0378-4274(81)90071-0
Source DB: PubMed Journal: Toxicol Lett ISSN： 0378-4274 Impact factor: 4.372