Literature DB >> 7218436

Adenovirus type 2 expresses fiber in monkey-human hybrids and reconstructed cells.

G A Zorn, C W Anderson.   

Abstract

Adenovirus type 2 protein expression was measured by indirect immunofluorescence in monkey-human hybrids and in cells reconstructed from monkey and human cell karyoplasts and cytoplasts. Monkey-human hybrid clones infected with adenovirus type 2 expressed fiber protein, whereas infected monkey cells alone did not. Hybrids constructed after the parental monkey cells were infected with adenovirus type 2 demonstrated that fiber synthesis in these cells could be rescued by fusion to uninfected human cells. Thus, human cells contain a dominant factor that acts in trans and overcomes the inability of monkey cells to synthesize fiber. Cells reconstructed from infected human karyoplasts and monkey cytoplasts expressed fiber, whereas cells reconstructed from infected monkey karyoplasts and human cytoplasts did not. These results are consistent with the hypothesis that the block to adenovirus replication in monkey cells involves a nuclear event that prevents the formation of functional mRNA for some late viral proteins including fiber polypeptide. Furthermore, they suggest that the translational apparatus of monkey cells is competent to translate functional fiber mRNA synthesized in human cells.

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Year:  1981        PMID: 7218436      PMCID: PMC171064     

Source DB:  PubMed          Journal:  J Virol        ISSN: 0022-538X            Impact factor:   5.103


  40 in total

1.  A nondefective (competent) adenovirus-SV40 hybrid isolated from the AD.2-SV40 hybrid population.

Authors:  A M Lewis; M J Levin; W H Wiese; C S Crumpacker; P H Henry
Journal:  Proc Natl Acad Sci U S A       Date:  1969-08       Impact factor: 11.205

2.  Nucleic acid homology studies of adenovirus type 7-SV40 interactions.

Authors:  P R Reich; S G Baum; J A Rose; W P Rowe; S M Weissman
Journal:  Proc Natl Acad Sci U S A       Date:  1966-02       Impact factor: 11.205

3.  Structural proteins of adenoviruses. I. Purification and characterization of the adenovirus type 2 hexon antigen.

Authors:  U Pettersson; L Philipson; S Höglund
Journal:  Virology       Date:  1967-12       Impact factor: 3.616

4.  Biochemical studies on adenovirus multiplication. XV. Transcription of the adenovirus type II genome during productive infection.

Authors:  D C Thomas; M Green
Journal:  Virology       Date:  1969-10       Impact factor: 3.616

5.  Enhancement of adenovirus plaque formation on HeLa cells by magnesium chloride.

Authors:  J F Williams
Journal:  J Gen Virol       Date:  1970-12       Impact factor: 3.891

6.  Interaction of a simian papovavirus and adenoviruses. I. Induction of adenovirus tumor antigen during abortive infection of simian cells.

Authors:  L A Feldman; J S Butel; F Rapp
Journal:  J Bacteriol       Date:  1966-02       Impact factor: 3.490

7.  Studies on nondefective adenovirus-simian virus 40 hybrid viruses. I. A newly characterized simian virus 40 antigen induced by the Ad2+ND 1 virus.

Authors:  A M Lewis; W P Rowe
Journal:  J Virol       Date:  1971-02       Impact factor: 5.103

8.  Studies on the mechanism of enhancement of adenovirus 7 infection in African green monkey cells by simian virus 40: formation of adenovirus-specific RNA.

Authors:  S G Baum; W H Wiese; P R Reich
Journal:  Virology       Date:  1968-02       Impact factor: 3.616

9.  Biochemical consequences of type 2 adenovirus and Simian virus 40 double infections of African green monkey kidney cells.

Authors:  M P Friedman; M J Lyons; H S Ginsberg
Journal:  J Virol       Date:  1970-05       Impact factor: 5.103

10.  Genetic analysis of simian virus 40. 3. Characterization of a temperature-sensitive mutant blocked at an early stage of productive infection in monkey cells.

Authors:  J A Robb; R G Martin
Journal:  J Virol       Date:  1972-06       Impact factor: 5.103

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  12 in total

1.  Defective synthesis of early region 4 mRNAs during abortive adenovirus infections in monkey cells.

Authors:  D Ross; E Ziff
Journal:  J Virol       Date:  1992-05       Impact factor: 5.103

2.  Characterization of the translational defect to fiber synthesis in monkey cells abortively infected with human adenovirus: role of ancillary leaders.

Authors:  L Silverman; D F Klessig
Journal:  J Virol       Date:  1989-10       Impact factor: 5.103

3.  Characterization of am404, an amber mutation in the simian virus 40 T antigen gene.

Authors:  D R Rawlins; P Collis; N Muzyczka
Journal:  J Virol       Date:  1983-07       Impact factor: 5.103

4.  Altered mRNA splicing in monkey cells abortively infected with human adenovirus may be responsible for inefficient synthesis of the virion fiber polypeptide.

Authors:  K P Anderson; D F Klessig
Journal:  Proc Natl Acad Sci U S A       Date:  1984-07       Impact factor: 11.205

5.  Microinjection of mRNA enhances translational efficiency of human adenovirus fiber message in monkey cells.

Authors:  K P Anderson; E A Wong; D F Klessig
Journal:  Mol Cell Biol       Date:  1985-10       Impact factor: 4.272

6.  Normal translation of human adenovirus mRNA in cell-free lysates prepared from abortively as well as productively infected monkey cells.

Authors:  M P Quinlan; D F Klessig
Journal:  J Virol       Date:  1982-10       Impact factor: 5.103

7.  Identification of key regulated events early in the life of hybrid animal cells constructed by nuclear transplantation.

Authors:  M J Hightower; J Bruno; J J Lucas
Journal:  Proc Natl Acad Sci U S A       Date:  1983-09       Impact factor: 11.205

8.  Adeno-associated virus helper activity of adenovirus DNA binding protein.

Authors:  R A McPherson; H S Ginsberg; J A Rose
Journal:  J Virol       Date:  1982-11       Impact factor: 5.103

9.  Abnormal expression of a late gene family L1 protein in monkey cells abortively infected with adenovirus type 2.

Authors:  C W Anderson; M M Hardy; J B Lewis
Journal:  Virus Genes       Date:  1988-03       Impact factor: 2.332

10.  Membrane interactions of simian virus 40 large T-antigen: influence of protein sequences and fatty acid acylation.

Authors:  U Klockmann; M Staufenbiel; W Deppert
Journal:  Mol Cell Biol       Date:  1984-08       Impact factor: 4.272

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