Literature DB >> 7217971

The effects of phenytoin on phenobarbitone and primidone metabolism.

D G Lambie, R H Johnson.   

Abstract

Serum concentrations of primidone and its metabolites-phenobarbitone and phenylethylmalonamide-were measured in 40 epileptic patients receiving treatment with primidone alone or primidone plus phenytoin. Serum phenobarbitone concentrations were also measured in 100 patients receiving phenobarbitone, alone or with phenytoin showed raised serum phenobarbitone concentrations. Phenytoin also caused raised phenylethylmalonamide concentrations in patients on primidone.

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Year:  1981        PMID： 7217971      PMCID： PMC490847          DOI： 10.1136/jnnp.44.2.148

Source DB:  PubMed          Journal:  J Neurol Neurosurg Psychiatry        ISSN： 0022-3050            Impact factor:   10.154


  8 in total

1.  Interaction of phenytoin and primidone.

Authors:  E H Reynolds; G Fenton; P Fenwick; A L Johnson; M Laundy
Journal:  Br Med J       Date:  1975-06-14

2.  The effect of anticonvulsant drugs which induce liver microsomal enzymes on derived and ingested phenobarbitone levels.

Authors:  N Callaghan; M Feely; F Duggan; M O'Callaghan; J Seldrup
Journal:  Acta Neurol Scand       Date:  1977-07       Impact factor: 3.209

3.  The influence of diphenylhydantoin on primidone metabolism.

Authors:  R W Fincham; D D Schottelius; A L Sahs
Journal:  Arch Neurol       Date:  1974-03

4.  A gas-chromatographic method for the simultaneous determination of phenobarbitone, primidone and phenytoin in serum using a nitrogen detector.

Authors:  J H Goudie; D Burnett
Journal:  Clin Chim Acta       Date:  1973-02-12       Impact factor: 3.786

5.  Interaction between phenobarbital and diphenylhydantoin in animals and in epileptic patients.

Authors:  P L Morselli; M Rizzo; S Garattini
Journal:  Ann N Y Acad Sci       Date:  1971-07-06       Impact factor: 5.691

6.  Phenylethylmalonamide (PEMA). An important metabolite of primidone.

Authors:  I P Baumel; B B Gallagher; R H Mattson
Journal:  Arch Neurol       Date:  1972-07

7.  The metabolic conversion of primidone (Mysoline) to phenobarbitone in patients under long-term treatment. An attempt to estimate the independent effect of primidone.

Authors:  O V Olesen; M Dam
Journal:  Acta Neurol Scand       Date:  1967       Impact factor: 3.209

8.  Therapeutic and pharmacokinetic effects of increasing phenytoin in chronic epileptics on multiple drug therapy.

Authors:  D G Lambie; R H Johnson; R N Nanda; R A Shakir
Journal:  Lancet       Date:  1976-08-21       Impact factor: 79.321
  8 in total
  6 in total

Review 1.  Pharmacokinetic drug interactions with phenytoin (Part II).

Authors:  R L Nation; A M Evans; R W Milne
Journal:  Clin Pharmacokinet       Date:  1990-02       Impact factor: 6.447

Review 2.  Pharmacokinetic interactions between antiepileptic drugs. Clinical considerations.

Authors:  R Riva; F Albani; M Contin; A Baruzzi
Journal:  Clin Pharmacokinet       Date:  1996-12       Impact factor: 6.447

Review 3.  Pharmacokinetic interactions with antiepileptic drugs.

Authors:  E Perucca
Journal:  Clin Pharmacokinet       Date:  1982 Jan-Feb       Impact factor: 6.447

Review 4.  Anticonvulsant drugs. An update.

Authors:  M J Eadie
Journal:  Drugs       Date:  1984-04       Impact factor: 9.546

5.  Phenytoin: an inhibitor and inducer of primidone metabolism in an epileptic patient.

Authors:  M G Porro; H J Kupferberg; R J Porter; W H Theodore; M E Newmark
Journal:  Br J Clin Pharmacol       Date:  1982-08       Impact factor: 4.335

Review 6.  Antiepileptic drugs. A review of clinically significant drug interactions.

Authors:  P N Patsalos; J S Duncan
Journal:  Drug Saf       Date:  1993-09       Impact factor: 5.606
  6 in total

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