Literature DB >> 7217049

The carcinogen chromate induces DNA cross-links in rat liver and kidney.

M J Tsapakos, T H Hampton, K W Jennette.   

Abstract

DNA cross-links were found in nuclei isolated from the liver and kidney of rats treated with chromate. A dose-dependent relationship between chromate exposure and total DNA cross-links was determined using the alkaline elution technique. DNA cross-links in kidney were mainly DNA-protein in nature. Chromate also induced a small amount of interstrand DNA cross-links in kidney. Liver nuclei contained protein-associated DNA single strand breaks in addition to DNA-protein cross-links. The organotropic DNA damage induced by chromate is discussed in relation to the carcinogenicity and toxicity of chromium(VI) compounds.

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Year:  1981        PMID： 7217049

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  10 in total

1.  Coordination chemistry and the carcinogenicity and mutagenicity of chromium(VI).

Authors:  P O'Brien; G Wang
Journal:  Environ Geochem Health       Date:  1989-12       Impact factor: 4.609

2.  Analytical and structural electron microscopy of chromium carcinogenesis in vitro.

Authors:  N A Coombs; G C Weatherly; R M Pilliar
Journal:  Biol Trace Elem Res       Date:  1989 Jul-Sep       Impact factor: 3.738

3.  The in vitro transformation of a rat liver epithelial cell line with chromium.

Authors:  J A Briggs; R C Briggs
Journal:  Biol Trace Elem Res       Date:  1989 Jul-Sep       Impact factor: 3.738

4.  A comparison of the effects of chromate, molybdate and cadmium oxide on respiration in the yeast Saccharomyces cerevisiae.

Authors:  G Henderson
Journal:  Biol Met       Date:  1989

5.  Nephrotoxicity of sodium dichromate depending on the route of administration.

Authors:  E Kim; K J Na
Journal:  Arch Toxicol       Date:  1991       Impact factor: 5.153

Review 6.  Assessment of the mode of action underlying development of rodent small intestinal tumors following oral exposure to hexavalent chromium and relevance to humans.

Authors:  Chad M Thompson; Deborah M Proctor; Mina Suh; Laurie C Haws; Christopher R Kirman; Mark A Harris
Journal:  Crit Rev Toxicol       Date:  2013-03       Impact factor: 5.635

7.  In vitro assessment of the toxicity of metal compounds : III. Effects of metals on DNA structure and function in intact cells.

Authors:  N T Christie; M Costa
Journal:  Biol Trace Elem Res       Date:  1983-02       Impact factor: 3.738

8.  In vitro assessment of the toxicity of metal compounds : IV. Disposition of metals in cells: Interactions with membranes, glutathione, metallothionein, and DNA.

Authors:  N T Christie; M Costa
Journal:  Biol Trace Elem Res       Date:  1984-04       Impact factor: 3.738

9.  Effect of nickel(II) on DNA-protein interactions.

Authors:  T P Coogan; D M Latta; R J Imbra; M Costa
Journal:  Biol Trace Elem Res       Date:  1989 Jul-Sep       Impact factor: 3.738

Review 10.  Molecular mechanisms of transformation of C3H/10T1/2 C1 8 mouse embryo cells and diploid human fibroblasts by carcinogenic metal compounds.

Authors:  J R Landolph
Journal:  Environ Health Perspect       Date:  1994-09       Impact factor: 9.031
  10 in total

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