Literature DB >> 721696

Mitotic rate of the rat's thyroid gland during hypertrophy induced by an antithyroid agent (carbimazole).

O Redmond, A R Tuffery.   

Abstract

Female rats (200 g body weight) were either untreated or given carbimazole (0.1 g/100 ml) in their drinking water for up to 12 weeks. The mitotic rate of the thyroid follicular cells was estimated using vincristine sulphate. Measurement of whole-body oxygen consumption showed that the rats were clearly hypothyroid after 1 week of treatment. The mitotic rate rose rapidly from the control value of 3.65% metaphases/day to about 25%/day after 4 days and was maintained at this level for at least 5 weeks of treatment. The changes in mitotic rate were apparently synchronous with the histological changes. The results of earlier studies are reviewed and discussed in relation to recent concepts of cell populations.

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Year:  1978        PMID： 721696      PMCID： PMC1235776     

Source DB:  PubMed          Journal:  J Anat        ISSN： 0021-8782            Impact factor:   2.610


  20 in total

1.  INFLUENCE OF PROPYLTHIOURACIL AND THYROXINE ON SYNTHESIS AND SECRETION OF THYROID-STIMULATING HORMONE IN THE HYPOTHYROID RAT.

Authors:  J L BAKKE; N LAWRENCE
Journal:  Acta Endocrinol (Copenh)       Date:  1964-05

2.  SIGNIFICANCE OF RATE OF RESPONSE OF BASAL METABOLIC RATE AND SERUM CHOLESTEROL IN HYPERTHYROID PATIENTS RECEIVING NEOMERCAZOLE AND OTHER ANTITHYROID AGENTS.

Authors:  E D FURTH; D V BECKER; M S SCHWARTZ
Journal:  J Clin Endocrinol Metab       Date:  1963-11       Impact factor: 5.958

3.  CLASSIFICATION OF CELL POPULATIONS ON THE BASIS OF THEIR PROLIFERATIVE BEHAVIOR.

Authors:  C P LEBLOND
Journal:  Natl Cancer Inst Monogr       Date:  1964-05

4.  THE EFFECT OF IRRADIATION ON THE FUNCTION AND SURVIVAL OF RAT THYROID CELLS.

Authors:  A Y AL-HINDAWI; G M WILSON
Journal:  Clin Sci       Date:  1965-06       Impact factor: 6.124

5.  Cell proliferation and migration as revealed by radioautography after injection of thymidine-H3 into male rats and mice.

Authors:  B MESSIER; C P LEBLOND
Journal:  Am J Anat       Date:  1960-05

6.  Daily variations in mitotic activity of adrenal cortex, thyroid and oral epithelium of the rat.

Authors:  H R MUHLEMANN; T M MARTHALER; P LOUSTALOT
Journal:  Proc Soc Exp Biol Med       Date:  1955-11

7.  Growth in the cell populations of the thyroid gland of rats treated with thiouracil.

Authors:  J E SANTLER
Journal:  J Endocrinol       Date:  1957-06       Impact factor: 4.286

8.  Effect of the cessation of thiouracil administration on the cell population of the thyroid of rats.

Authors:  J E SANTLER
Journal:  J Endocrinol       Date:  1957-11       Impact factor: 4.286

9.  Renewal of cell populations.

Authors:  C P LEBLOND; B E WALKER
Journal:  Physiol Rev       Date:  1956-04       Impact factor: 37.312

10.  [Mitosis periods in adrenal cortex, thyroid and duodenal and oral cavity epithelium in rats].

Authors:  T M MARTHALER; H R MUHLEMANN; K H RATEITSCHAK
Journal:  Acta Anat (Basel)       Date:  1956
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  2 in total

1.  Thyroid proliferation, body weight, thyrotropin and thyroid hormones in chronic antithyroid (carbimazole) treatment in rats.

Authors:  O Redmond; A R Tuffery
Journal:  J Anat       Date:  1981-08       Impact factor: 2.610

2.  Mitotic rate of thyroid follicular cells in untreated and goitrogen-treated rats: variation with time of day.

Authors:  O Redmond; A R Tuffery
Journal:  J Anat       Date:  1979-12       Impact factor: 2.610
  2 in total

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