Literature DB >> 7215003

Radioimmunoassay of gentamicin in microliter and nanoliter samples of biological fluids.

A Meulemans, C Manuel, P Tran Ba Huy.   

Abstract

A gentamicin radioimmunoassay is described for microliter and nanoliter samples. The assay was performed in the inner ears' fluids (perilymph and endolymph) of rats. Endolymph and perilymph samples were collected under oil with a glass capillary micropipette. The absolute threshold of sensitivity was 20 . 10(-12) g. Considering the maximum sampling volume, 15--400 . 10(-9) and 10 . 16(-6) l for endolymph and perilymph respectively, the limit of detection is 4.19 . 10(-4) microM . ml-1 in endolymph, 1.26 . 10(-4) microM . ml-1 in perilymph. Clinical applications of this method are suggested.

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Year:  1981        PMID： 7215003     DOI： 10.1159/000237951

Source DB:  PubMed          Journal:  Chemotherapy        ISSN： 0009-3157            Impact factor:   2.544


  10 in total

1.  A new immunohistochemical method for the detection of gentamicin in inner ear fluid compartments.

Authors:  M Mihelic-Rapp; W Giebel
Journal:  Eur Arch Otorhinolaryngol       Date:  1996       Impact factor: 2.503

2.  Acquired gentamicin resistance by permeability impairment in Enterococcus faecalis.

Authors:  Elisabeth Aslangul; Laurent Massias; Alain Meulemans; Françoise Chau; Antoine Andremont; Patrice Courvalin; Bruno Fantin; Raymond Ruimy
Journal:  Antimicrob Agents Chemother       Date:  2006-11       Impact factor: 5.191

3.  Effect of fetal exposure to gentamicin on kidneys of young guinea pigs.

Authors:  M Lelievre-Pegorier; T Gilbert; R Sakly; A Meulemans; C Merlet-Benichou
Journal:  Antimicrob Agents Chemother       Date:  1987-01       Impact factor: 5.191

4.  Comparison of a simplified liquid chromatographic assay of gentamicin in serum with enzyme immunoassay and bioassay.

Authors:  L Essers
Journal:  Eur J Clin Microbiol       Date:  1982-12       Impact factor: 3.267

5.  Continuous sampling for determination of pharmacokinetics in rat cerebrospinal fluid.

Authors:  A Meulemans; P Vicart; J Mohler; M Vulpillat; J J Pocidalo
Journal:  Antimicrob Agents Chemother       Date:  1986-12       Impact factor: 5.191

6.  Comparative uptake of gentamicin, netilmicin, and amikacin in the guinea pig cochlea and vestibule.

Authors:  D Dulon; J M Aran; G Zajic; J Schacht
Journal:  Antimicrob Agents Chemother       Date:  1986-07       Impact factor: 5.191

7.  Kinetics of gentamicin uptake and release in the rat. Comparison of inner ear tissues and fluids with other organs.

Authors:  P Tran Ba Huy; P Bernard; J Schacht
Journal:  J Clin Invest       Date:  1986-05       Impact factor: 14.808

8.  Gentamicin persistence in rat endolymph and perilymph after a two-day constant infusion.

Authors:  P Tran Ba Huy; A Meulemans; M Wassef; C Manuel; O Sterkers; C Amiel
Journal:  Antimicrob Agents Chemother       Date:  1983-02       Impact factor: 5.191

9.  Influence of antimicrobial therapy on kinetics of tumor necrosis factor levels in experimental endocarditis caused by Klebsiella pneumoniae.

Authors:  J Mohler; B Fantin; J L Mainardi; C Carbon
Journal:  Antimicrob Agents Chemother       Date:  1994-05       Impact factor: 5.191

10.  Kinetics of gentamicin in plasma of nonpregnant, pregnant, and fetal guinea pigs and its distribution in fetal tissues.

Authors:  M Lelievre-Pegorier; R Sakly; A Meulemans; C Merlet-Benichou
Journal:  Antimicrob Agents Chemother       Date:  1985-10       Impact factor: 5.191
  10 in total

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