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Literature DB >> 7214147

Role of intracortical inhibition in deprivation amblyopia: reversal by microiontophoretic bicuculline.

Abstract

The GABA antagonist, bicuculline, was microiontophoretically applied to 31 cells in the visual cortices of 4 cats monocularly deprived of vision from birth to time of study at age 5 months. Bicuculline restored input from the deprived eye to 42% of cells studied. Elevation of background firing rates by glutamate failed to restore deprived eye input. We suggest that intracortical inhibition plays an important role in maintaining the physiological abnormalities produced in visual cortex by monocular deprivation.

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Year: 1981 PMID： 7214147 DOI： 10.1016/0006-8993(81)90551-5

Source DB: PubMed Journal: Brain Res ISSN： 0006-8993 Impact factor: 3.252

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Cited

17 in total

1. Synaptic density in geniculocortical afferents remains constant after monocular deprivation in the cat.

Authors: M A Silver; M P Stryker
Journal: J Neurosci Date: 1999-12-15 Impact factor: 6.167

2. Distributions of synaptic vesicle proteins and GAD65 in deprived and nondeprived ocular dominance columns in layer IV of kitten primary visual cortex are unaffected by monocular deprivation.

Authors: M A Silver; M P Stryker
Journal: J Comp Neurol Date: 2000-07-10 Impact factor: 3.215

Role of intracortical inhibition in deprivation amblyopia: reversal by microiontophoretic bicuculline.

1. Synaptic density in geniculocortical afferents remains constant after monocular deprivation in the cat.

2. Distributions of synaptic vesicle proteins and GAD65 in deprived and nondeprived ocular dominance columns in layer IV of kitten primary visual cortex are unaffected by monocular deprivation.

3. Nonlinear responses of simple cells to Mach band stimuli: evidence from early monocularly deprived cats.

4. The morphology of retinogeniculate X- and Y-cell axonal arbors in dark-reared cats.

Review 5. The anatomy of geniculocortical connections in monocularly deprived cats.

Review 6. Glutamate, GABA, and CNS disease: a review.

7. Brief monocular deprivation leaves subthreshold synaptic input on neurones of the cat's visual cortex.

8. Bidirectional ocular dominance plasticity of inhibitory networks: recent advances and unresolved questions.

9. Developmental changes in GABAergic mechanisms in human visual cortex across the lifespan.

10. Deficient responses from the lateral geniculate nucleus in humans with amblyopia.