Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Differential effect of benserazide (Ro4-4602) on the concentration of indoleamines in rat pineal and hypothalamus.

Literature DB >> 7214095

Differential effect of benserazide (Ro4-4602) on the concentration of indoleamines in rat pineal and hypothalamus.

J Arendt, A K Ho, C Laud, A Marston, V Nohria, J A Smith, A M Symons.

Abstract

1 Low doses (50 and 80 mg/kg) of benserazide (Ro4-4602), an aromatic amino acid decarboxylase inhibitor, markedly reduced 5-hydroxytryptamine and melatonin in the rat pineal gland without affecting hypothalamic 5-hydroxytryptamine. 2 This differential effect shows that inhibition of the pineal gland decarboxylase activity is possible, and confirms that the rat pineal gland is accessible to peripherally acting agents.

Entities: Chemical Disease Species

Mesh：

Substances：

Year: 1981 PMID： 7214095 PMCID： PMC2071522 DOI： 10.1111/j.1476-5381.1981.tb09122.x

Source DB: PubMed Journal: Br J Pharmacol ISSN： 0007-1188 Impact factor: 8.739

20 in total

1. Melatonin may be synthesised in enterochromaffin cells.

Authors: N T Raikhlin; I M Kvetnoy; V N Tolkachev
Journal: Nature Date: 1975-05-22 Impact factor: 49.962

2. Increase of cerebral catecholamines caused by 3,4-dihydroxyphenylalanine after inhibition of peripheral decarboxylase.

Authors: G Bartholini; W P Burkard; A Pletscher
Journal: Nature Date: 1967-08-19 Impact factor: 49.962

Differential effect of benserazide (Ro4-4602) on the concentration of indoleamines in rat pineal and hypothalamus.

1. Melatonin may be synthesised in enterochromaffin cells.

2. Increase of cerebral catecholamines caused by 3,4-dihydroxyphenylalanine after inhibition of peripheral decarboxylase.

3. Brain serotonin content: physiological regulation by plasma neutral amino acids.

4. Hydroxyindole-O-methyl transferases in rat pineal, retina and harderian gland.

5. Brain serotonin concentration: elevation following intraperitoneal administration of melatonin.

6. Differences in circadian rhythms in 5-hydroxytryptamine according to brain region.

7. A sensitive and specific fluorescence assay for tissue serotonin.

8. The regulation of pineal serotonin by a beta adrenergic receptor.

9. Changes in rat pineal stores of 5-hydroxytryptamine after inhibition of its synthesis or break-down.

10. Presence of melatonin in plasma and urine or pinealectomized rats.

1. The effect of chronic antidepressant administration on beta-adrenoceptor function of the rat pineal.

2. Atenolol reduces plasma melatonin concentration in man.

3. Monitoring of circadian fluctuations of N-acetylserotonin in the rat pineal body by differential pulse voltammetry.