Literature DB >> 7213431

Interaction between rheumatoid factor and antibody/DNA complexes: enhancement of complement fixation.

D A Birchmore, R P Taylor, S J Waller, J S Davis, K W Morley.   

Abstract

The influence of rheumatoid factor (RF) on the complement mediated binding of antibody/double-stranded DNA immune complexes to red blood cells has been investigated. Our results indicate that RF enhances this binding reaction, apparently by fixing complement via its own Fc region. These findings suggest that under certain circumstances, RF may play an exacerbating role in the antibody/DNA induced glomerulonephritis of systemic lupus erythematosus.

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Year:  1981        PMID： 7213431     DOI： 10.1002/art.1780240313

Source DB:  PubMed          Journal:  Arthritis Rheum        ISSN： 0004-3591


  5 in total

1.  DNA antibodies with and without complement-binding ability.

Authors:  A M Teppo; P Kurki; T Helve; O Wegelius
Journal:  Rheumatol Int       Date:  1984       Impact factor: 2.631

2.  Reduction of the complement activation capacity of soluble IgG aggregates and immune complexes by IgM-rheumatoid factor.

Authors:  G Doekes; J Schouten; A Cats; M R Daha
Journal:  Immunology       Date:  1985-07       Impact factor: 7.397

3.  Studies of artificial cryoprecipitates containing anti-DNA antibody activity.

Authors:  R P Taylor; S J Waller; J S Davis; J B Winfield; K W Morley; E L Wright
Journal:  Rheumatol Int       Date:  1981       Impact factor: 2.631

4.  Circulating DNA-antibodies in systemic lupus erythematosus.

Authors:  T Helve; A M Teppo; P Kurki; O Wegelius
Journal:  Rheumatol Int       Date:  1982       Impact factor: 2.631

Review 5.  Clearance of cryoglobulins in man.

Authors:  Y C Ng; J A Schifferli
Journal:  Springer Semin Immunopathol       Date:  1988
  5 in total

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