Literature DB >> 7212797

Screening for liver metastases from colorectal cancer with carcinoembryonic antigen and alkaline phosphatase.

P I Tartter, G Slater, I Gelernt, A H Aufses.   

Abstract

A sensitive and economic method of screening for liver metastases in patients with colorectal cancer was developed using serum alkaline phosphatase and carcinoembryonic antigen. The upper limit of normal for alkaline phosphatase and carcinoembryonic antigen did not represent the optimal levels for use in predicting liver metastases. However, with alkaline phosphatase greater than 135 I.U., and/or carcinoembryonic antigen greater than 10 ng/ml, sensitivity was 88%: 23 of 26 patients with liver metastases fulfilled either or both criteria. The false-positive rate was 12%. Liver scanning, alone, demonstrated metastases in only 69% of 35 patients with liver metastases. The combination of alkaline phosphatase and carcinoembryonic antigen can be used economically to screen for liver metastases, and to determine which patients should undergo a liver scan.

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Year:  1981        PMID： 7212797      PMCID： PMC1345076          DOI： 10.1097/00000658-198103000-00019

Source DB:  PubMed          Journal:  Ann Surg        ISSN： 0003-4932            Impact factor:   12.969


  25 in total

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Journal:  Clin Chem       Date:  1965-09       Impact factor: 8.327

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  14 in total

1.  Serum alkaline phosphatase and 30-day mortality after surgery for spinal metastatic disease.

Authors:  Aditya V Karhade; Quirina C B S Thio; Paul T Ogink; Joseph H Schwab
Journal:  J Neurooncol       Date:  2018-09-01       Impact factor: 4.130

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Journal:  World J Gastroenterol       Date:  2010-08-28       Impact factor: 5.742

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Journal:  Ann Surg       Date:  1985-02       Impact factor: 12.969

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Authors:  S Bhattacharjya; R Aggarwal; B R Davidson
Journal:  Br J Cancer       Date:  2006-07-03       Impact factor: 7.640

10.  Measurement of high molecular weight forms of enzymes in serum in the detection of hepatic metastases of colorectal cancer.

Authors:  O J Traynor; C B Wood; Z O Echetebu; K B Whitaker; D W Moss
Journal:  Br J Cancer       Date:  1986-04       Impact factor: 7.640
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