Literature DB >> 7211845

2-deoxy-glucose-6-phosphate utilization in the study of glucose-6-phosphate dehydrogenase mosaicism.

A M Ferraris, P Giuntini, S Galiano, G F Gaetani.   

Abstract

The electrophoretic difference between normal glucose-6-phosphate dehydrogenase (G6PD) and two common variants (G6PD A and G6PD A-) has made the G6PD enzyme system very useful for genetic studies and for investigation on the clonal origin of tumors. This approach has not been possible for another common variant, G6PD mediterranean, which has a normal electrophoretic pattern. The different utilization of 2-deoxy-glucose-6-phosphate (2dG6P), an analog of the normal substrate, by the normal enzyme and the Mediterranean variant, allows a convenient determination of the degree of mosaicism in mononuclear cells from heterozygotes.

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Year:  1981        PMID： 7211845      PMCID： PMC1684947     

Source DB:  PubMed          Journal:  Am J Hum Genet        ISSN： 0002-9297            Impact factor:   11.025


  14 in total

1.  Further studies on the properties and assay of glucose 6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase of rat liver.

Authors:  G E GLOCK; P McLEAN
Journal:  Biochem J       Date:  1953-10       Impact factor: 3.857

2.  Clonal origin of human tumors.

Authors:  P J Fialkow
Journal:  Biochim Biophys Acta       Date:  1976-10-12

3.  Protein measurement with the Folin phenol reagent.

Authors:  O H LOWRY; N J ROSEBROUGH; A L FARR; R J RANDALL
Journal:  J Biol Chem       Date:  1951-11       Impact factor: 5.157

4.  Utilization of eponychium for genetic studies.

Authors:  E Gandini; G Zecchi
Journal:  Am J Hum Genet       Date:  1973-01       Impact factor: 11.025

5.  Abnormalities of the hexose monophosphate shunt.

Authors:  E Beutler
Journal:  Semin Hematol       Date:  1971-10       Impact factor: 3.851

6.  Glucose-6-phosphate dehydrogenase mosaicism for studying the development of blood cell precursors.

Authors:  E Gandini; S M Gartler
Journal:  Nature       Date:  1969-11-08       Impact factor: 49.962

Review 7.  Clonal origin of human tumors.

Authors:  P J Fialkow
Journal:  Annu Rev Med       Date:  1979       Impact factor: 13.739

8.  Genetic diversity of the "Mediterranean" glucose-6-phosphate dehydrogenase deficiency phenotype.

Authors:  G Stamatoyannopoulos; V Voigtlander; P Kotsakis; A Akrivakis
Journal:  J Clin Invest       Date:  1971-06       Impact factor: 14.808

9.  Prenatal diagnosis by linkage: hemophilia A and polymorphic glucose-6-phosphate deydrogenase.

Authors:  C J Edgell; H N Kirkman; E Clemons; P D Buchanan; C H Miller
Journal:  Am J Hum Genet       Date:  1978-01       Impact factor: 11.025

10.  Allelic exclusion of glucose-6-phosphate dehydrogenase in platelets and T lymphocytes from a Wiskott-Aldrich syndrome carrier.

Authors:  W J Gealy; J M Dwyer; J B Harley
Journal:  Lancet       Date:  1980-01-12       Impact factor: 79.321
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  5 in total

1.  Glucose 6-phosphate dehydrogenase deficiency and incidence of hematologic malignancy.

Authors:  A M Ferraris; G Broccia; T Meloni; G Forteleoni; G F Gaetani
Journal:  Am J Hum Genet       Date:  1988-03       Impact factor: 11.025

2.  A case of ataxia telangiectasia with unbalanced glucose 6-phosphate dehydrogenase mosaicism in the granulocytic/monocytic lineages.

Authors:  A M Ferraris; C Melani; L Canepa; T Meloni; G Forteleoni; G F Gaetani
Journal:  Am J Hum Genet       Date:  1987-01       Impact factor: 11.025

3.  Cell surface abnormality in clones of skin fibroblasts from a carrier of Duchenne muscular dystrophy.

Authors:  J Hillier; G E Jones; H E Statham; J A Witkowski; V Dubowitz
Journal:  J Med Genet       Date:  1985-04       Impact factor: 6.318

4.  A prospective comparison between treatment with phlebotomy alone and with interferon-alpha in patients with polycythemia vera.

Authors:  S Sacchi; P Leoni; M Liberati; A Riccardi; A Tabilio; P Tartoni; C Messora; A Vecchi; L Bensi; S Rupoli
Journal:  Ann Hematol       Date:  1994-05       Impact factor: 3.673

5.  Diverse point mutations in the human glucose-6-phosphate dehydrogenase gene cause enzyme deficiency and mild or severe hemolytic anemia.

Authors:  T J Vulliamy; M D'Urso; G Battistuzzi; M Estrada; N S Foulkes; G Martini; V Calabro; V Poggi; R Giordano; M Town
Journal:  Proc Natl Acad Sci U S A       Date:  1988-07       Impact factor: 11.205
  5 in total

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