| Literature DB >> 7208563 |
W Perry, R U Esposito, C Kornetsky.
Abstract
Rats were tested on a rate-free psychophysical procedure in order to determine the absolute reinforcement thresholds for self-stimulation behavior. The administration of naloxone (16 mg/kg) for five days failed to alter the reinforcement thresholds on this procedure. To the extent that naloxone is an effective antagonist of endogenous opioids, we conclude that central endorphin systems are not necessary to support self-stimulation behavior.Entities:
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Year: 1981 PMID： 7208563 DOI： 10.1016/0091-3057(81)90251-3
Source DB: PubMed Journal: Pharmacol Biochem Behav ISSN： 0091-3057 Impact factor: 3.533