Literature DB >> 7207634

Metabolism of 3H-noradrenaline released from isolated rat hypothalamus by extracts of black widow spider glands.

J F Pardal, A R Granata, A Barrio, A L Gimeno.   

Abstract

In the isolated rat hypothalamus preincubated with 3H-noradrenaline, an extract from the venom glands of Latrodectus mactans elicited on overflow of tritium which consisted of 70--71% 3H-noradrenaline and 18% 3H-3,4-dihydroxyphenylglycol. Exposure to cocaine or pargyline diminished the formation of 3H-3,4-dihydroxyphenylglycol, suggesting that the glycol is formed presynaptically after neuronal reuptake of the transmitter released by the venom. Our data suggest that the venom depolarizes the noradrenergic neurones of rat hypothalamus, and that the depolarization leads to calcium-dependent release of 3H-noradrenaline.

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Year:  1980        PMID： 7207634     DOI： 10.1007/bf00505801

Source DB:  PubMed          Journal:  Naunyn Schmiedebergs Arch Pharmacol        ISSN： 0028-1298            Impact factor:   3.000


  18 in total

1.  Presynaptic receptor systems on the noradrenergic neurones of rat brain.

Authors:  H D Taube; K Starke; E Borowski
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1977-09       Impact factor: 3.000

2.  Effects of black widow spider venom on the frog neuromuscular junction. Effects on end-plate potential, miniature end-plate potential and nerve terminal spike.

Authors:  H E Longenecker; W P Hurlbut; A Mauro; A W Clark
Journal:  Nature       Date:  1970-02-21       Impact factor: 49.962

3.  Tetrodotoxin and neuromuscular transmission.

Authors:  B Katz; R Miledi
Journal:  Proc R Soc Lond B Biol Sci       Date:  1967-01-31

4.  Preferential metabolism of (-) 3 H-norepinephrine through the deaminated glycol in the rat vas deferens.

Authors:  K H Graffe; F J Stefano; S Z Langer
Journal:  Biochem Pharmacol       Date:  1973-05-15       Impact factor: 5.858

5.  Disappearance of small vesicles from adrenergic nerve endings in the rat vas deferens caused by red back spider venom.

Authors:  R C Hamilton; P M Robinson
Journal:  J Neurocytol       Date:  1973-12

6.  Effects of black widow spider venom on acetylcholine release from rat cerebral cortex slices in vitro.

Authors:  N Frontali; F Granata; P Parisi
Journal:  Biochem Pharmacol       Date:  1972-04-01       Impact factor: 5.858

7.  Serological relationship of the lethal components of two black widow spider venoms.

Authors:  J D McCrone; R J Hatala
Journal:  Toxicon       Date:  1968-08       Impact factor: 3.033

8.  Release of noradrenaline from the cat spleen by potassium.

Authors:  S M Kirpekar; A R Wakade
Journal:  J Physiol       Date:  1968-02       Impact factor: 5.182

9.  Effects of nicotine on distribution and release of 14C-norepinephrine and 14C-dopamine in rat brain striatum and hypothalamus slices.

Authors:  F R Goodman
Journal:  Neuropharmacology       Date:  1974-11       Impact factor: 5.250

10.  The release of acetylcholine elicited by extracts of black widow spider glands: studies using rat superior cervical ganglia and inhibitors of electrically stimulated release.

Authors:  D W Pumplin; W O McClure
Journal:  J Pharmacol Exp Ther       Date:  1977-05       Impact factor: 4.030
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  1 in total

1.  Effects of estradiol on norepinephrine and prostaglandin efflux in medial basal hypothalamus of ovariectomized rats.

Authors:  D P Cardinali; J Fernández Pardal; M F Gimeno; A L Gimeno
Journal:  J Neural Transm       Date:  1982       Impact factor: 3.575
  1 in total

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