Literature DB >> 7205881

Synthesis and antidepressant activity of substituted (omega-aminoalkoxy)benzene derivatives.

R Kikumoto, A Tobe, S Tonomura.   

Abstract

A series of substituted (omega-aminoalkoxy)benzene derivatives has been synthesized and screened for potential antidepressant activities. The effect of structural variation of these molecules has been systematically examined. Antidepressant activity was clearly displayed by 2-benzyl-1-[4-(methylamino)butoxy]benzene (7), 2-(2-hydroxybenzyl)-1-[4-(methylamino)butoxy]benzene (19), 1-[4-(methylamino)butoxy]-2-phenoxybenzene (29), and 1-[4-(methylamino)butoxy]-2-(phenylthio)benzene (31) in further pharmacological studies. These compounds did not possess the anticholinergic, antihistaminic, and muscle-relaxant side effects common to tricyclic antidepressants.

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Year:  1981        PMID： 7205881     DOI： 10.1021/jm00134a004

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


  4 in total

1.  A Practical Electrophilic Nitrogen Source for the Synthesis of Chiral Primary Amines by Copper-Catalyzed Hydroamination.

Authors:  Sheng Guo; Jeffrey C Yang; Stephen L Buchwald
Journal:  J Am Chem Soc       Date:  2018-11-08       Impact factor: 15.419

2.  Selective potentiation of noradrenaline in the guinea-pig vas deferens by 2-(4-methylaminobutoxy) diphenylmethane hydrochloride (MCI-2016), a new psychotropic drug.

Authors:  Y Ohizumi; M Takahashi; A Tobe
Journal:  Br J Pharmacol       Date:  1982-02       Impact factor: 8.739

3.  Synthesis and anti-HCMV activity of 1-[ω-(phenoxy)alkyl]uracil derivatives and analogues thereof.

Authors:  Mikhail S Novikov; Denis A Babkov; Maria P Paramonova; Anastasia L Khandazhinskaya; Alexander A Ozerov; Alexander O Chizhov; Graciela Andrei; Robert Snoeck; Jan Balzarini; Katherine L Seley-Radtke
Journal:  Bioorg Med Chem       Date:  2013-05-16       Impact factor: 3.641

4.  Toward the discovery of dual HCMV-VZV inhibitors: Synthesis, structure activity relationship analysis, and cytotoxicity studies of long chained 2-uracil-3-yl-N-(4-phenoxyphenyl)acetamides.

Authors:  Denis A Babkov; Anastasia L Khandazhinskaya; Alexander O Chizhov; Graciela Andrei; Robert Snoeck; Katherine L Seley-Radtke; Mikhail S Novikov
Journal:  Bioorg Med Chem       Date:  2015-09-21       Impact factor: 3.641
  4 in total

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