Literature DB >> 7205879

1-(Naphthylalkyl)-1H-imidazole derivatives, a new class of anticonvulsant agents.

K A Walker, M B Wallach, D R Hirschfeld.   

Abstract

Potent anticonvulsant activity has been demonstrated for a large number of 1-(naphthylalkyl)-1H-imidazoles containing a variety of functional groups in the alkylene bridge. The presence of a small oxygen function in the bridge, in general, confers a high therapeutic index between anticonvulsant and depressant activity. Clinical expectations are discussed for 1-(2-naphthoylmethyl)imidazole hydrochloride (5), which is undergoing development for testing in humans.

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Year:  1981        PMID： 7205879     DOI： 10.1021/jm00133a015

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


  5 in total

1.  Azole derivatives with naphthalene showing potent antifungal effects against planktonic and biofilm forms of Candida spp.: an in vitro and in silico study.

Authors:  Suat Sari; Ebru Koçak; Didem Kart; Zeynep Özdemir; M Fahir Acar; Burcu Sayoğlu; Arzu Karakurt; Sevim Dalkara
Journal:  Int Microbiol       Date:  2020-09-05       Impact factor: 2.479

2.  Investigation of the mechanism of enantioseparation of some drug compounds by considering the mobile phase in HPLC by molecular dynamics simulation.

Authors:  Hamideh Barfeii; Zahra Garkani-Nejad; Vahid Saheb
Journal:  J Mol Model       Date:  2019-09-03       Impact factor: 1.810

Review 3.  Dextromethorphan binding sites in the guinea pig brain.

Authors:  J M Musacchio; M Klein
Journal:  Cell Mol Neurobiol       Date:  1988-06       Impact factor: 5.046

4.  Toxicological Screening of 4-Phenyl-3,4-dihydrobenzo[h]quinolin-2(1H)-one: A New Potential Candidate for Alzheimer's Treatment.

Authors:  Fareeha Anwar; Uzma Saleem; Atta Ur Rehman; Bashir Ahmad; Tariq Ismail; Muhammad Usman Mirza; Lee Yean Kee; Iskandar Abdullah; Sarfraz Ahmad
Journal:  ACS Omega       Date:  2021-04-16

5.  Comparative Molecular Similarity Indices Analysis of 1-(Naphthylalky1)-1H-imidazole Analogs with Antiepileptic Activity.

Authors:  S Ganguly; R Mishra
Journal:  J Young Pharm       Date:  2010-10
  5 in total

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