Literature DB >> 720530

Tissue distribution and nucleic acid binding of chlorambucil-3H in tumor-bearing rats.

K D Tew, D M Taylor.   

Abstract

In tumour and normal rat tissues prolonged alkylation of DNA and RNA by chlorambucil-3H occurs over periods of 24 h. It is suggested that this may indicate the slow release of an alkylating moiety from an intracellular drug-macromolecule complex.

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Year:  1978        PMID： 720530     DOI： 10.1007/bf01922965

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  7 in total

Review 1.  ALKYLATING AGENTS.

Authors:  P BROOKES; P D LAWLEY
Journal:  Br Med Bull       Date:  1964-05       Impact factor: 4.291

2.  Some studies of the active intermediates formed in the microsomal metabolism of cyclophosphamide and isophosphamide.

Authors:  T A Connors; P J Cox; P B Farmer; A B Foster; M Jarman
Journal:  Biochem Pharmacol       Date:  1974-01-01       Impact factor: 5.858

3.  Selectivity of action of alkylating agents and drug resistance. 4. Synthesis of tritium-labeled chlorambucil and a study of its cellular uptake by drug-sensitive and drug-resistant strains of the Yoshida ascites sarcoma in vitro.

Authors:  B T Hill; M Jarman; K R Harrap
Journal:  J Med Chem       Date:  1971-07       Impact factor: 7.446

4.  The binding of [3H]chlorambucil to nuclear proteins of the Yoshida ascites sarcoma.

Authors:  P G Riches; K R Harrap
Journal:  Chem Biol Interact       Date:  1975-10       Impact factor: 5.192

5.  Some studies on the distribution and effects of cyclophosphamide (NSC-26271) in normal and neoplastic tissue.

Authors:  P J Houghton; K D Tew; D M Taylor
Journal:  Cancer Treat Rep       Date:  1976-04

6.  Studies with cyclophosphamide labeled with phosphorus-32: nucleic acid alkylation and its effect on DNA synthesis in rat tumor and normal tissues.

Authors:  K D Tew; D M Taylor
Journal:  J Natl Cancer Inst       Date:  1977-05       Impact factor: 13.506

7.  The absorption, distribution and excretion of 3 H-chlorambucil in rats bearing the Yoshida ascites sarcoma.

Authors:  B T Hill; P G Riches
Journal:  Br J Cancer       Date:  1971-12       Impact factor: 7.640
  7 in total

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