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Literature DB >> 7205249

The effect of intraperitoneal injection of GABA or GHBA on monoamine histofluorescence in the rat brain.

Abstract

Using the Falck-Hillarp histofluorescence method we studied the effect of gamma-aminobutyric acid (GABA) or gamma-hydroxybutyric acid (GHBA) on catecholaminergic (CA) and serotoninergic (5-HT) neurons in the rat brain. Both GABA as well as GHBA enhanced the CA fluorescence in noradrenergic (NA) terminals in the cerebellar cortex, which suggested that the NA content increased in these terminals. GHBA but not GABA also enhanced the fluorescence in dopaminergic (DA) terminals in the neostriatum and limbic structures. No significant changes of fluorescence were found in 5-HT neurons after both compounds. The results obtained suggest that, apart from the known GABA-DA interaction, there exists also a GABA-NA interaction in the cerebellar cortex.

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Year: 1981 PMID： 7205249 DOI： 10.1007/bf01254915

Source DB: PubMed Journal: J Neural Transm Impact factor: 3.575

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References

28 in total

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Authors: J R Walters; R H Roth; G K Aghajanian
Journal: J Pharmacol Exp Ther Date: 1973-09 Impact factor: 4.030

The effect of intraperitoneal injection of GABA or GHBA on monoamine histofluorescence in the rat brain.

1. Noradrenergic neurons of the locus coeruleus: inhibition by epinephrine and activation by the alpha-antagonist piperoxane.

2. Baclofen and gamma-hydroxybutyrate: similar effects on cerebral dopamine neurones.

3. Selective accumulation of ( 3 H)GABA by stellate cells in rat cerebellar cortex in vivo.

4. Effects of drugs influencing monoamine mechanisms on the increase in brain dopamine produced by axotomy or treatment with gammahydroxybutyric acid.

5. Increase in brain dopamine after axotomy or treatment with gammahydroxybutyric acid due to elimination of the nerve impulse flow.

6. Dopaminergic neurons: similar biochemical and histochemical effects of gamma-hydroxybutyrate and acute lesions of the nigro-neostriatal pathway.

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