Literature DB >> 720480

Separation and quantitative determination of imipramine and desipramine from rat biological samples by high pressure liquid chromatography.

A Bonora, P A Borea.   

Abstract

Imipramine and its metabolite, desipramine, have been determined in several rat biological samples by high pressure liquid chromatography. The method allows one to detect 15 ng in column of both drugs with a lower sensitivity limit of 20 microgram1-(1).

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Year:  1978        PMID： 720480     DOI： 10.1007/bf01932369

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  11 in total

1.  A method for the determination of imipramine in human plasma by gas-liquid chromatography-mass fragmentography.

Authors:  A Frigerio; G Belvedere; F De Nadai; R Fanelli; C Pantarotto; E Riva; P L Morselli
Journal:  J Chromatogr       Date:  1972-12-20

2.  Metabolism of 14C-imipramine. II. Urinary metabolites in man.

Authors:  J L Crammer; B Scott; B Rolfe
Journal:  Psychopharmacologia       Date:  1969

3.  The total fate of a drug: kinetics of distribution, excretion, and formation of 14 metabolites in rats treated with imipramine.

Authors:  M H Bickel; H J Weder
Journal:  Arch Int Pharmacodyn Ther       Date:  1968-06

4.  A method for the measurement of plasma imipramine and desmethylimipramine concentrations.

Authors:  S R Harris; L E Gaudette; D H Efron; A A Manian
Journal:  Life Sci I       Date:  1970-07-15

5.  Separation and determination of imipramine and its metabolites from biological samples by gas-liquid chromatography.

Authors:  H J Weder; M H Bickel
Journal:  J Chromatogr       Date:  1968-10-08

6.  Quantitative determination of imipramine and desipramine in human blood plasma by direct densitometry of thin-layer chromatograms.

Authors:  A Nagy; L Treiber
Journal:  J Pharm Pharmacol       Date:  1973-08       Impact factor: 3.765

7.  Plasma levels of imipramine and desmethylimipramine during therapy.

Authors:  J P Moody; A C Tait; A Todrick
Journal:  Br J Psychiatry       Date:  1967-02       Impact factor: 9.319

8.  Blood and brain concentrations of imipramine, clomipramine and their monomethylated metabolites after oral and intramuscular administration in rats.

Authors:  A Nagy
Journal:  J Pharm Pharmacol       Date:  1977-02       Impact factor: 3.765

9.  Imipramine metabolism in man. A study of urinary metabolites after administration of radioactive imipramine.

Authors:  J Christiansen; L F Gram; B Kofod; O J Rafaelsen
Journal:  Psychopharmacologia       Date:  1967-08-04

10.  SPECIES DIFFERENCES IN THE METABOLISM OF IMIPRAMINE AND DESMETHYLIMIPRAMINE (DMI).

Authors:  J V DINGELL; F SULSER; J R GILLETTE
Journal:  J Pharmacol Exp Ther       Date:  1964-01       Impact factor: 4.030
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