Literature DB >> 7203728

Pharmacokinetics of amitriptyline in the elderly.

J F Henry, C Altamura, R Gomeni, M P Hervy, F Forette, P L Morselli.   

Abstract

The pharmacokinetics of amitryptyline (AMI) have been evaluated in six healthy elderly volunteers (72-83 years of age) after a single dose of 125 mg of AMI-HCl. AMI was absorbed rather slowly (mean peak time 10.4 +/- 1.6 hrs) but very efficiently (F: 0.59-0.75). The rate of formation of nortriptyline (NT) as well as the appearance clearance values (0.18-0.45 l/h/kg) of AMI were significantly lower than those previously described for younger subjects. Reversible alterating ECG were observed in 5 cases concomitantly with AMI peak plasma concentrations. The results indicate the desirability of reduced and/or divided daily doses of AMI in the elderly.

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Year:  1981        PMID： 7203728

Source DB:  PubMed          Journal:  Int J Clin Pharmacol Ther Toxicol        ISSN： 0174-4879


  8 in total

Review 1.  Age-related changes in antidepressant pharmacokinetics and potential drug-drug interactions: a comparison of evidence-based literature and package insert information.

Authors:  Richard D Boyce; Steven M Handler; Jordan F Karp; Joseph T Hanlon
Journal:  Am J Geriatr Pharmacother       Date:  2012-01-27

Review 2.  Pharmacokinetic Variability of Drugs Used for Prophylactic Treatment of Migraine.

Authors:  Peer Tfelt-Hansen; Frederik Nybye Ågesen; Agniezka Pavbro; Jacob Tfelt-Hansen
Journal:  CNS Drugs       Date:  2017-05       Impact factor: 5.749

Review 3.  Discrepancies between pharmacokinetic studies of amitriptyline.

Authors:  P Schulz; P Dick; T F Blaschke; L Hollister
Journal:  Clin Pharmacokinet       Date:  1985 May-Jun       Impact factor: 6.447

4.  Influence of age on mianserin pharmacokinetics.

Authors:  A C Altamura; T Melorio; G Invernizzi; R Gomeni
Journal:  Psychopharmacology (Berl)       Date:  1982       Impact factor: 4.530

5.  The demethylation of amitriptyline: a cross-over study of steady-state plasma levels of amitriptyline and nortriptyline in depressed patients.

Authors:  J E Burch
Journal:  Psychopharmacology (Berl)       Date:  1983       Impact factor: 4.530

6.  Age-related differences in kinetics and side-effects of viloxazine in man and their clinical implications.

Authors:  A C Altamura; T Melorio; G Invernizzi; F Colacurcio; R Gomeni
Journal:  Psychopharmacology (Berl)       Date:  1983       Impact factor: 4.530

7.  Age differences in effects on blood pressure, flicker fusion frequency, salivation and pharmacokinetics of single oral doses of dothiepin and amitriptyline.

Authors:  C Ogura; A Kishimoto; R Mizukawa; H Hazama; H Honma; K Kawahara
Journal:  Eur J Clin Pharmacol       Date:  1983       Impact factor: 2.953

Review 8.  Clinical pharmacokinetics of antidepressants in the elderly. Therapeutic implications.

Authors:  L L von Moltke; D J Greenblatt; R I Shader
Journal:  Clin Pharmacokinet       Date:  1993-02       Impact factor: 6.447
  8 in total

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