Literature DB >> 7203172

Shape and functional properties of human platelets washed with acid citrate.

H Patscheke.   

Abstract

Acid citrate pH 6.5 protects human platelets from activation during washing at room temperature. Platelets suspended in media containing citrate pH 6.5 have an extra-flat disc shape. Citrate at pH 6.5 also inhibits the ADP-induced shape change. When warmed to 37 degrees C and suspended into the test medium of pH 7.4, the washed platelets aggregate with low concentrations of ADP or epinephrine in the presence of fibrinogen and Ca2+. The morphological and functional quality of platelet concentrates (6 X 10(6) microliter-1) stored in acid citrate pH 6.5 is maintained for at least 6 h at room temperature.

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Year:  1981        PMID： 7203172     DOI： 10.1159/000214383

Source DB:  PubMed          Journal:  Haemostasis        ISSN： 0301-0147


  11 in total

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