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Literature DB >> 720317

In vitro preparation of infarcted myocardium.

Abstract

An isolated ventricular endocardial preparation removed from canine hearts one to two days after coronary artery occlusion and superfused in vitro is described. The alteration in electrophysiological characteristics of subendocardial Purkinje fibers surviving in infarcted regions and the relationship of these changes to the generation of ventricular arrhythmias is discussed. The advantages of such preparations for assessing the mechanism of action of antiarrhythmic drugs in post-infarction ventricular arrhythmias is discussed.

Entities: Disease Species

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Year: 1978 PMID： 720317 PMCID： PMC1637270 DOI： 10.1289/ehp.7826233

Source DB: PubMed Journal: Environ Health Perspect ISSN： 0091-6765 Impact factor: 9.031

11 in total

1. Effect of lidocaine and quinidine on steady-state characteristics and recovery kinetics of (dV/dt)max in guinea pig ventricular myocardium.

Authors: C M Chen; L S Gettes; B G Katzung
Journal: Circ Res Date: 1975-07 Impact factor: 17.367

2. Effectiveness of bretylium tosylate against refractory ventricular arrhythmias.

Authors: J G Bernstein; J Koch-Weser
Journal: Circulation Date: 1972-05 Impact factor: 29.690

3. Electrophysiologic effects of bretylium tosylate on single fibers of the canine specialized conducting system and ventricle.

Authors: A L Wit; C Steiner; A N Damato
Journal: J Pharmacol Exp Ther Date: 1970-06 Impact factor: 4.030

In vitro preparation of infarcted myocardium.

1. Effect of lidocaine and quinidine on steady-state characteristics and recovery kinetics of (dV/dt)max in guinea pig ventricular myocardium.

2. Effectiveness of bretylium tosylate against refractory ventricular arrhythmias.

3. Electrophysiologic effects of bretylium tosylate on single fibers of the canine specialized conducting system and ventricle.

4. Electrophysiological properties of canine Purkinje cells in one-day-old myocardial infarction.

5. Survival of subendocardial Purkinje fibers after extensive myocardial infarction in dogs.

6. The effect of bretylium tosylate on the electrophysiologic properties of ventricular muscle and Purkinje fibers.

7. Electrophysiological propertiesf the canine peripheral A-V conducting system.

8. Electrophysiological actions of lidocaine on canine ventricular muscle and Purkinje fibers.

9. Electrophysiological effects of bretylium tosylate on subendocardial Purkinje fibers from infarcted canine hearts.

10. Effect of lidocaine on the electrophysiological properties of ventricular muscle and purkinje fibers.