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Literature DB >> 7202882

Buformin concentrations in a case of fatal lactic acidosis.

L F Verdonck, B Sangster, A N van Heijst, G de Groot, R A Maes.

Abstract

A fatal case of lactic acidosis in a 84 year old diabetic woman taking buformin is reported. Buformin concentrations in serum, other body fluids and tissues were measured by gas chromatography. Serum buformin concentration at admission was 5.5 mg/l. Postmortem concentrations were: in serum 3.2 mg/l; in lung 2.8 mg/kg wet weight; in heart 3.0 mg/kg; in pericardial fluid 3.5 mg/l; in liver 5.2 mg/kg; in bile 6.3 mg/l; and in kidney 98 mg/kg.

Entities: Chemical Disease Species

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Year: 1981 PMID： 7202882 DOI： 10.1007/bf00253815

Source DB: PubMed Journal: Diabetologia ISSN： 0012-186X Impact factor: 10.122

13 in total

1. [10 cases of lactic acidosis during biguanide therapy (buformin and phenformin)].

Authors: W Berger; S Mehnert-Aner; K Mülly; C Heierli; R Ritz
Journal: Schweiz Med Wochenschr Date: 1976-12-11

2. [Investigations of the mode action of buformin using a 3H-labelled glucose in people with a healthy metabolism (author's transl)].

Authors: P Bottermann; U Schweigart; R Ermler
Journal: Med Klin Date: 1976-09-03

Buformin concentrations in a case of fatal lactic acidosis.

1. [10 cases of lactic acidosis during biguanide therapy (buformin and phenformin)].

2. [Investigations of the mode action of buformin using a 3H-labelled glucose in people with a healthy metabolism (author's transl)].

3. Butylbiguanide concentration in plasma, liver, and intestine after intravenous and oral administration to man.

4. Effects of acute lactic acidosis on left ventricular performance.

5. Lactic acidosis.

6. Effects of changes of pH and of carbon dioxide tension on left ventricular performance.

7. [The risk of lacticate acidosis: a comparison of the 3 biguanides in treatment of diabetics (authors' transl)].

8. [Lactacidosis in biguanide therapy: diagnosis and therapy. 4 cases compared to 179 cases in the world literature].

9. [Lactic acidosis--a possible complication in buformin-treated diabetics (author's transl)].

10. Evaluation of a sustained release form of the oral antidiabetic butylbiguanide (Silubin retard).

Review 1. Pharmacokinetic-pharmacodynamic relationships of oral hypoglycaemic agents. An update.