Literature DB >> 7202707

Synthesis of new psychotropic 2-imidazolidinones.

L Fontanella, N Corsico, A Diena, G Galliani, A Glässer.   

Abstract

The report describes the synthesis and pharmacology of some new derivatives of 1-(m or p-chlorophenyl)-2-imidazolidinone. These compounds were obtained either by reacting an amine with an N-(2-chloroethyl)-2-imidazolidinone or by reacting a 2-chloroethylamine with an N-substituted-2-imidazolidinone. Two compounds (II f, h) showed interesting psychotropic activity.

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Year:  1981        PMID： 7202707

Source DB:  PubMed          Journal:  Farmaco Sci        ISSN： 0430-0920


  4 in total

1.  Structural requirements of Na+-dependent antidopaminergic agents: Tropapride, Piquindone, Zetidoline, and Metoclopramide. Comparison with Na+-independent ligands.

Authors:  S Collin; D P Vercauteren; D Vanderveken; G Evrard; F Durant
Journal:  J Comput Aided Mol Des       Date:  1989-03       Impact factor: 3.686

2.  Metabolic fate of zetidoline, a new neuroleptic agent, in man.

Authors:  A Assandri; A Perazzi; P Ferrari; E Martinelli; A Ripamonti; G Tarzia; G Tuan
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1985-01       Impact factor: 3.000

3.  A comparison of some psychological and physiological effects exerted by zetidoline (DL308) and by oxazepam.

Authors:  M Herbert; P J Standen; A H Short; A T Birmingham
Journal:  Psychopharmacology (Berl)       Date:  1983       Impact factor: 4.530

4.  Effects of acute administration of zetidoline, a new antidopaminergic drug, on plasma prolactin and aldosterone levels in man.

Authors:  C Barbieri; M Parodi; S Bruno; F Bertassi; D Benaglia; P Moser; R Meroni; A Dubini
Journal:  Eur J Clin Pharmacol       Date:  1984       Impact factor: 2.953
  4 in total

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