| Literature DB >> 7202521 |
R C Hill, R Maurer, H H Buescher, D Roemer.
Abstract
The analgesic properties of the muscimol analogue THIP (4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol) in laboratory animals were compared with those of baclofen, morphine and muscimol. THIP was active orally and parenterally and resembled muscimol qualitatively in its actions. Quantitatively, THIP and baclofen were 2--3 times less potent than morphine and 5--15 times less potent than muscimol. The analgesic effects of THIP, baclofen and muscimol were not reversed by naloxone or bicuculline.Entities:
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Year: 1981 PMID： 7202521 DOI： 10.1016/0014-2999(81)90419-2
Source DB: PubMed Journal: Eur J Pharmacol ISSN： 0014-2999 Impact factor: 4.432