Literature DB >> 7200396

Acute nephrotoxicity following cis-dichlorodiammine-platinum.

J D Bitran, R K Desser, A A Billings, M F Kozloff, C M Shapiro.   

Abstract

The effects of a single dose of cis-diamminedichloroplatinum (DDP) on the kidney function were investigated in 14 patients with disseminated malignancy and normal renal function. A single dose of DDP (30-50 mg/m2) caused severe proximal tubular dysfunction with increased urinary losses of calcium, magnesium, and amino acids. Phosphate excretion was not affected. DDP can cause proximal tubular dysfunction and close attention must be paid to serum calcium and magnesium levels.

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Year:  1982        PMID： 7200396     DOI： 10.1002/1097-0142(19820501)49:9<1784::aid-cncr2820490909>3.0.co;2-6

Source DB:  PubMed          Journal:  Cancer        ISSN： 0008-543X            Impact factor:   6.860


  17 in total

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Review 9.  Cisplatin: a review of clinical applications and renal toxicity.

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10.  Renal function, serum calcium and magnesium during treatment of advanced bladder carcinoma with cis-dichlorodiamineplatinum: impact of tumour site, patient age and magnesium suppletion.

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