Literature DB >> 7200262

Prenatal exposure to phenobarbital permanently decreases testosterone and causes reproductive dysfunction.

C Gupta, S J Yaffe, B H Shapiro.   

Abstract

Exposure of rats to phenobarbital during late prenatal development decreased the concentration of testosterone in plasma and the brain during the late fetal, early postnatal, pubertal, and adult periods, By decreasing the production of testosterone in the brain during the period of sexual differentiation, phenobarbital may lead to sexual dysfunction in later life.

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Year:  1982        PMID： 7200262     DOI： 10.1126/science.7200262

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  5 in total

1.  Activation of CAR and PXR by Dietary, Environmental and Occupational Chemicals Alters Drug Metabolism, Intermediary Metabolism, and Cell Proliferation.

Authors:  J P Hernandez; L C Mota; W S Baldwin
Journal:  Curr Pharmacogenomics Person Med       Date:  2009-06-01

2.  Autism and the use of hypnotic barbiturates in obstetrics and pediatrics.

Authors:  R A Jensen
Journal:  J Autism Dev Disord       Date:  1991-06

3.  Potential risk factors for brain tumors in children. An analysis of 200 cases.

Authors:  R Giuffrè; G Liccardo; F S Pastore; A Spallone; R Vagnozzi
Journal:  Childs Nerv Syst       Date:  1990-01       Impact factor: 1.475

4.  Impact of Neonatal Activation of Nuclear Receptor CAR (Nr1i3) on Cyp2 Gene Expression in Adult Mouse Liver.

Authors:  Aram Shin; David J Waxman
Journal:  Toxicol Sci       Date:  2022-05-26       Impact factor: 4.109

5.  Phenobarbitone: adverse effects on reproductive performance and offspring development in the Mongolian gerbil, (Meriones unguiculatus).

Authors:  J B Chapman; M G Cutler
Journal:  Psychopharmacology (Berl)       Date:  1988       Impact factor: 4.530
  5 in total

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