| Literature DB >> 7200183 |
Abstract
Administration of estrogen to rats during the period of withdrawal from chronic haloperidol attenuated the characteristic increase in apomorphine-induced stereotypy and the increase in (3H) spiroperidol binding. This apparent ability of estrogen to "down-regulate" brain dopamine receptors could lead to useful pharmacological treatments of tardive dyskinesia and possibly of other hyperdopaminergic states.Entities:
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Year: 1982 PMID： 7200183 DOI： 10.1016/0024-3205(82)90503-3
Source DB: PubMed Journal: Life Sci ISSN： 0024-3205 Impact factor: 5.037