Literature DB >> 7199361

Identical triplets: non-identical psychosis?

P McGuffin, A Reveley, A Holland.   

Abstract

In contrast to all previous reports of psychoses in genetically identical siblings, identical triplets aged 28 were discordant by major Kraepelinian type of psychosis. Two of them had been diagnosed schizophrenic while the third was diagnosed manic depressive. Re-evaluation of their illnesses using standardized methods and diagnosis by blind raters suggested that the discordance was not due to simple misdiagnosis or different diagnostic bias between psychiatrists. These triplets illustrate some of the shortcomings of a strictly applied Kraepelinian dichotomy and show that a genetic perspective is important in attempting to resolve the classificatory problems of atypical psychoses.

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Year:  1982        PMID: 7199361     DOI: 10.1192/bjp.140.1.1

Source DB:  PubMed          Journal:  Br J Psychiatry        ISSN: 0007-1250            Impact factor:   9.319


  10 in total

Review 1.  Structural cerebral variations as useful endophenotypes in schizophrenia: do they help construct "extended endophenotypes"?

Authors:  Konasale M Prasad; Matcheri S Keshavan
Journal:  Schizophr Bull       Date:  2008-04-11       Impact factor: 9.306

Review 2.  The G72/G30 gene locus in psychiatric disorders: a challenge to diagnostic boundaries?

Authors:  Rami Abou Jamra; Christine Schmael; Sven Cichon; Marcella Rietschel; Johannes Schumacher; Markus M Nöthen
Journal:  Schizophr Bull       Date:  2006-08-16       Impact factor: 9.306

Review 3.  Genetics of bipolar disorder.

Authors:  N Craddock; I Jones
Journal:  J Med Genet       Date:  1999-08       Impact factor: 6.318

Review 4.  The genetics of schizophrenia and bipolar disorder: dissecting psychosis.

Authors:  N Craddock; M C O'Donovan; M J Owen
Journal:  J Med Genet       Date:  2005-03       Impact factor: 6.318

5.  Dementia praecox and manic-depressive insanity in 1908: a Grade of Membership analysis of the Kraepelinian dichotomy.

Authors:  A Jablensky; M A Woodbury
Journal:  Eur Arch Psychiatry Clin Neurosci       Date:  1995       Impact factor: 5.270

Review 6.  DNA markers and biological vulnerability markers in families multiply affected with schizophrenia.

Authors:  D Blackwood; D St Clair; W Muir
Journal:  Eur Arch Psychiatry Clin Neurosci       Date:  1991       Impact factor: 5.270

7.  A set of male monozygotic triplets with schizophrenic psychoses: nature or nurture?

Authors:  C Härnryd; E Jönsson; D Greitz; H Nyman; G Sedvall
Journal:  Eur Arch Psychiatry Clin Neurosci       Date:  1995       Impact factor: 5.270

Review 8.  Genes for schizophrenia and bipolar disorder? Implications for psychiatric nosology.

Authors:  Nick Craddock; Michael C O'Donovan; Michael J Owen
Journal:  Schizophr Bull       Date:  2005-11-30       Impact factor: 9.306

Review 9.  The genetic deconstruction of psychosis.

Authors:  Michael J Owen; Nick Craddock; Assen Jablensky
Journal:  Schizophr Bull       Date:  2007-06-05       Impact factor: 9.306

10.  Monozygotic twins with early-onset schizophrenia and late-onset bipolar disorder: a case report.

Authors:  Richard O'Reilly; E Fuller Torrey; Jay Rao; Shiva Singh
Journal:  J Med Case Rep       Date:  2013-05-28
  10 in total

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