| Literature DB >> 7199323 |
T B Vree, A M Baars, L H Booij, J J Driessen.
Abstract
A HPLC (high performance liquid chromatography) method for the determination of 8-chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a] [1,4]benzodiazepine (midazolam, Ro 21-3981, Dormicum) and its hydroxy metabolites has been developed. The half-life of elimination of midazolam and the glucuronides of the metabolites 1-hydroxymethyl-midazolam, 4-hydroxy-midazolam and 1-hydroxymethyl-4-hydroxy-midazolam are identical, 53 min in dogs and 90 min in man.Entities:
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Year: 1981 PMID： 7199323
Source DB: PubMed Journal: Arzneimittelforschung ISSN： 0004-4172