Do cholinomimetics specifically antagonize rotational behavior?

Asymmetries of body posture and movement (rotational behavior) following intracerebral application of dopamine (DA, 200 micrograms/2 microliters) or carbachol (30 and 60 micrograms/2 microliters) were diminished by systemically applied oxotremorine (0.5-1.0 mg/kg IP). The combined intracerebral injections of DA and carbachol show localization-specific effects in caudate nucleus, substantia nigra and globus pallidus. The experiments point to specific dopaminergic-cholinergic interaction in different brain regions. Systemically applied cholinomimetics exert a generally suppressive action on motoric effects.